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POP1 Antibody

  • 货号：
    CSB-PA018372GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q99575
  • 基因名：
    POP1
  • 别名：
    4932434G09Rik antibody; hPOP1 antibody; KIAA0061 antibody; MGC17365 antibody; MGC36536 antibody; POP1 antibody; POP1_HUMAN antibody; Processing of precursor 1 antibody; Processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) antibody; Processing of precursors 1 antibody; Ribonucleases P/MRP protein subunit homolog antibody; Ribonucleases P/MRP protein subunit POP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human POP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
  • 基因功能参考文献：
    1. Biallelic POP1 mutations were identified in both. A missense mutation and a novel single base deletion were detected in proband 1, p.[Pro582Ser]:[Glu870fs*5]. Markedly reduced abundance of RMRP and elevated levels of pre5.8s rRNA was observed. In proband 2, a homozygous novel POP1 mutation was identified PMID: 28067412
    2. we reported the third case with POP1-related AAD. This phenotype may appropriately be termed AAD type 2. PMID: 27380734
    3. by inhibiting inflammasome assembly, provides a regulatory feedback loop that shuts down excessive inflammatory responses; Cryopyrin-Associated Periodic Syndrome patients exhibit reduced expression PMID: 26275995
    4. S-palmitoylation alters conformation or secondary structure of Trx1, as well as decreases the ability of Trx1 to transfer electrons from thioredoxin reductase to S-nitrosylated protein-tyrosine phosphatase 1B and S-nitroso-glutathione PMID: 25839653
    5. Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-trna 5' processing. PMID: 22991464
    6. POP1 gene expression is increased in classic variant of papillary thyroid carcinoma. PMID: 21509594
    7. A transient association of protein subunits may be inversely correlated to its involvement in pre-rRNA processing. PMID: 16723659

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  • 相关疾病：
    Anauxetic dysplasia 2 (ANXD2)
  • 亚细胞定位：
    Nucleus, nucleolus.
  • 数据库链接：

    HGNC: 30129

    OMIM: 602486

    KEGG: hsa:10940

    STRING: 9606.ENSP00000339529

    UniGene: Hs.252828