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POLR3H Antibody

  • 货号：
    CSB-PA007793
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using POLR3H Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y535
  • 基因名：
    POLR3H
  • 别名：
    POLR3H antibody; KIAA1665 antibody; RPC8 antibody; DNA-directed RNA polymerase III subunit RPC8 antibody; RNA polymerase III subunit C8 antibody; DNA-directed RNA polymerase III subunit H antibody; RNA polymerase III subunit 22.9 kDa subunit antibody; RPC22.9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human POLR3H.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
  • 基因功能参考文献：
    1. Findings reveal that RNA polymerase III-dependent EBER expression through induction of cellular transcription factors and add to the repertoire of EBNA1's transcription-regulatory properties. PMID: 20843307
    2. The s demonstrate the interaction of both RNA polymerase I and III with hepatitis delta virus RNA, both in vitro and in human cells. PMID: 19246067
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Eukaryotic RPB7/RPC8 RNA polymerase subunit family
  • 数据库链接：

    HGNC: 30349

    KEGG: hsa:171568

    STRING: 9606.ENSP00000347345

    UniGene: Hs.712617