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POLR2G Antibody

  • 货号：
    CSB-PA018334LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, K562 whole cell lysate, HL60 whole cell lysate
      All lanes: POLR2G antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 20 kDa
      Observed band size: 20 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POLR2G Polyclonal antibody
  • Uniprot No.：
    P62487
  • 基因名：
    POLR2G
  • 别名：
    DNA directed RNA polymerase II 19 kDa polypeptide antibody; DNA directed RNA polymerase II subunit G antibody; DNA directed RNA polymerase II subunit RPB7 antibody; DNA-directed RNA polymerase II subunit G antibody; DNA-directed RNA polymerase II subunit RPB7 antibody; hRPB19 antibody; hsRPB7 antibody; MGC138367 antibody; MGC138369 antibody; POLR2G antibody; polymerase (RNA) II (DNA directed) polypeptide G antibody; RNA polymerase II 19 kDa subunit antibody; RNA polymerase II subunit B7 antibody; RPB19 antibody; RPB7 antibody; RPB7_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DNA-directed RNA polymerase II subunit RPB7 protein (1-172AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POLR2G Antibody (CSB-PA018334LA01HU)，的标记方式是Non-conjugated。对于POLR2G Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018334LB01HU POLR2G Antibody, HRP conjugated ELISA
    FITC CSB-PA018334LC01HU POLR2G Antibody, FITC conjugated
    Biotin CSB-PA018334LD01HU POLR2G Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA.
  • 基因功能参考文献：
    1. The function of Rpb7 interaction with rpb4 in human cells indicate that Rpb7 have gene-specific effects but are also more generally required for human cell survival. PMID: 23073835
    2. Identification of the RNA binding region of Rpb7. PMID: 16282592
    3. the emerging transcript cross-links to the Rpb7 subunit of RNA polymerase II in various complexes containing 26- to 32-nt transcripts PMID: 16327806
    4. TFIIF and Rpb7 are involved in both early and late transcriptional stages PMID: 17848138
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Eukaryotic RPB7/RPC8 RNA polymerase subunit family
  • 数据库链接：

    HGNC: 9194

    OMIM: 602013

    KEGG: hsa:5436

    STRING: 9606.ENSP00000301788

    UniGene: Hs.14839