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POLR2C Antibody

  • 货号：
    CSB-PA018329GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P19387
  • 基因名：
    POLR2C
  • 别名：
    DNA directed RNA polymerase II 33 kDa polypeptide antibody; DNA directed RNA polymerase II subunit C antibody; DNA directed RNA polymerase II subunit RPB3 antibody; DNA-directed RNA polymerase II 33 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit C antibody; DNA-directed RNA polymerase II subunit RPB3 antibody; hRPB33 antibody; hsRPB3 antibody; POLR 2C antibody; POLR2 C antibody; Polr2c antibody; Polymerase (RNA) II (DNA directed) polypeptide C; 33kDa antibody; polymerase RNA II DNA directed polypeptide C 33kDa antibody; RNA polymerase II polypeptide C antibody; RNA polymerase II subunit 3 antibody; RNA polymerase II subunit B3 antibody; RPB 3 antibody; RPB3 antibody; RPB3_HUMAN antibody; RPB31 antibody; RPB33 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human POLR2C
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft.
  • 基因功能参考文献：
    1. FUS low-complexicity phase separates to recruit RNA polymerase II C-terminal domain in vitro. PMID: 26455390
    2. These findings suggest that N-terminus of Rpb3 selectively inhibits Rpb3-high-expression hepatocellular carcinoma cells proliferation. N-terminus of Rpb3 may be useful in treating patients diagnosed with Rpb3-high-expression hepatocellular carcinoma. PMID: 25211001
    3. eEF1gamma, in addition to its role in translation elongation complex, is involved in regulating Vimentin gene by contacting both pol II and the Vimentin promoter region and shuttling/nursing the Vimentin mRNA PMID: 21217813
    4. interaction between RPB3 and ATF4 PMID: 12860379
    5. Rpb3 is a potential nuclear target of insulin-like growth factor binding protein-3 PMID: 16455777

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family
  • 数据库链接：

    HGNC: 9189

    OMIM: 180663

    KEGG: hsa:5432

    STRING: 9606.ENSP00000219252

    UniGene: Hs.79402