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POLR2B Antibody

  • 货号：
    CSB-PA018328GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P30876
  • 基因名：
    POLR2B
  • 别名：
    POLR2B antibody; DNA-directed RNA polymerase II subunit RPB2 antibody; EC 2.7.7.6 antibody; DNA-directed RNA polymerase II 140 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit B antibody; RNA polymerase II subunit 2 antibody; RNA polymerase II subunit B2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human POLR2B-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template.
  • 基因功能参考文献：
    1. Studies indicate transcription of many genes, is regulated after the initiation step, by pausing of RNA polymerase II during elongation through the promoter-proximal region. PMID: 21081187
    2. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation PMID: 12050112
    3. The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of magnesium and is required for both for the polymerization and cleavage reactions. PMID: 15886393
    4. the human Maf1 protein negatively regulates transcription by all three nuclear Pols, Pol I, Pol II and Pol III PMID: 17499043
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RNA polymerase beta chain family
  • 数据库链接：

    HGNC: 9188

    OMIM: 180661

    KEGG: hsa:5431

    STRING: 9606.ENSP00000312735

    UniGene: Hs.602757