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POLDIP2 Antibody

  • 货号：
    CSB-PA018307GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2S7
  • 基因名：
    POLDIP2
  • 别名：
    38 kDa DNA polymerase delta interaction protein antibody; delta interacting protein 2 antibody; DNA polymerase delta interaction protein p38 antibody; p38 antibody; PDIP 2 antibody; PDIP 38 antibody; PDIP2 antibody; PDIP2_HUMAN antibody; PDIP38 antibody; POLD 4 antibody; POLD4 antibody; Poldip2 antibody; Polymerase (DNA directed) delta interacting protein 2 antibody; Polymerase delta interacting protein 38 antibody; Polymerase delta-interacting protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human POLDIP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1).
  • 基因功能参考文献：
    1. Increasing mitochondrial lipoylation by forced expression of Poldip2 increases respiration and reduces the growth rate of cancer cells. Study unveils a regulatory mechanism of catabolic enzymes required for metabolic plasticity and highlights the role of Poldip2 as key during hypoxia and cancer cell metabolic adaptation. PMID: 29434038
    2. findings establish that PolDIP2 can regulate the translesion synthesis polymerase and primer extension activities of PrimPol PMID: 26984527
    3. POLDIP2 plays a crucial role in Tau aggregation via the impairment of autophagy activity, providing insight into Tau aggregation in Tau pathology. PMID: 25930997
    4. PDIP38 can respond to genotoxic or transcriptional stresses by undergoing translocation to the spliceosomes, where it is a required participant in the regulation of MDM2 alternative splicing. PMID: 23989611
    5. DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. PMID: 24191025
    6. We demonstrate that PDIP38 (Poldelta interacting protein of 38kDa) directly interacts with the TLS polymerase Poleta. PDIP38 is able to interact directly not only with Poleta but also with the specialized polymerases Rev1 and Polzeta (via Rev7). PMID: 20554254
    7. suggest that the TNFAIP1/POLDIP2 complex sense-antisense architecture represents a clinically significant transcriptional structural-functional gene module associated with amplification of the genomic region on 17q11.2 in breast cancer. PMID: 20158880
    8. PDIP38 might play a role in the pol delta-mediated viral DNA replication PMID: 15811854
    9. PDIP38 is located in the mitochondrial matrix. TFAM and mitochondrial single-stranded DNA binding protein (mtSSB) are co-immunoprecipitated with PDIP38 PMID: 16428295
    10. PDIP38 can shuttle between the cytoplasmic and the nuclear compartments and that its subcellular localization is regulated by CEACAM1 PMID: 17623671
    11. Poldip2 associates with p22phox to activate Nox4, leading to regulation of focal adhesion turnover and vascular smooth muscle cell migration, thus linking reactive oxygen species production and cytoskeletal remodeling. PMID: 19574552

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  • 亚细胞定位：
    Mitochondrion matrix. Nucleus.
  • 数据库链接：

    HGNC: 23781

    OMIM: 611519

    KEGG: hsa:26073

    UniGene: Hs.241543