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POC5 Antibody

  • 货号：
    CSB-PA843309LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA843309LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POC5 Polyclonal antibody
  • Uniprot No.：
    Q8NA72
  • 基因名：
    POC5
  • 别名：
    C5orf37 antibody; Centrosomal protein POC5 antibody; FLJ35779 antibody; hPOC5 antibody; MGC120442 antibody; MGC120443 antibody; MGC120444 antibody; OTTHUMP00000222116 antibody; OTTHUMP00000222453 antibody; Poc5 antibody; POC5 centriolar protein antibody; POC5 centriolar protein homolog (Chlamydomonas) antibody; POC5 centriolar protein homolog antibody; POC5_HUMAN antibody; Protein of centriole 5 antibody; Proteome of centriole 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein POC5 protein (373-485AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POC5 Antibody (CSB-PA843309LA01HU)，的标记方式是Non-conjugated。对于POC5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA843309LB01HU POC5 Antibody, HRP conjugated ELISA
    FITC CSB-PA843309LC01HU POC5 Antibody, FITC conjugated
    Biotin CSB-PA843309LD01HU POC5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for the assembly of the distal half of centrioles, required for centriole elongation.
  • 基因功能参考文献：
    1. Common variant rs6892146 of POC5 is associated with the development of adolescent idiopathic scoliosis in the Chinese population. PMID: 29189569
    2. Depletion of CEP295 blocks the incorporation of POC5 and POC1B into the distal portion of centrioles and suppresses the post-translational modification of centriolar microtubules . Our study thus uncovers a new role for CEP295 during centriole elongation. PMID: 27185865
    3. Mutations in the POC5 gene contribute to the occurrence of idiopathic scoliosis. PMID: 25642776
    4. Data indicate that overexpression of the centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures. PMID: 23844208
    5. hPOC5, a conserved centrin-binding protein that contains Sfi1p-like repeats is characterized. PMID: 19349582

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the distal portion of centrioles.
  • 蛋白家族：
    POC5 family
  • 数据库链接：

    HGNC: 26658

    OMIM: 617880

    KEGG: hsa:134359

    STRING: 9606.ENSP00000410216

    UniGene: Hs.432726