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PNLIPRP2 Antibody

  • 货号：
    CSB-PA018264LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate
      All lanes: PNLIPRP2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52 kDa
      Observed band size: 52 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018264LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PNLIPRP2 Polyclonal antibody
  • Uniprot No.：
    P54317
  • 基因名：
    PNLIPRP2
  • 别名：
    EC 3.1.1.3 antibody; Galactolipase antibody; LIPR2_HUMAN antibody; Pancreatic lipase-related protein 2 antibody; PL-RP2 antibody; PLRP2 antibody; Pnliprp2 antibody; Secretory glycoprotein GP 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pancreatic lipase-related protein 2 protein (305-460AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PNLIPRP2 Antibody (CSB-PA018264LA01HU)，的标记方式是Non-conjugated。对于PNLIPRP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018264LB01HU PNLIPRP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA018264LC01HU PNLIPRP2 Antibody, FITC conjugated
    Biotin CSB-PA018264LD01HU PNLIPRP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.
  • 基因功能参考文献：
    1. findings show that endosomal lipases participate in lipid antigen presentation by processing lipid antigens and have a role in T cell immunity against mycobacteria PMID: 27662254
    2. The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 PMID: 26494624
    3. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. PMID: 23732775
    4. BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol. PMID: 21865348
    5. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns PMID: 21652702
    6. localization of PLRP2 in endosomes of monocytes PMID: 21554982
    7. Investigation of the substrate specificity of purified recombinant pancreatic lipase-related protein 2 reveals that its physiological role is digestion of galactolipids, the main plant lipids present in the vegetables which are a part of the human diet. PMID: 15287741
    8. Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects. PMID: 16887271
    9. finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media. PMID: 17401110
    10. Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2 PMID: 18702514
    11. The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes. PMID: 19548271

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  • 亚细胞定位：
    Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection.
  • 蛋白家族：
    AB hydrolase superfamily, Lipase family
  • 组织特异性：
    Pancreas.
  • 数据库链接：

    HGNC: 9157

    OMIM: 604423

    KEGG: hsa:5408

    UniGene: Hs.423598