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PNLIP Antibody

  • 货号：
    CSB-PA132878
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA132878(PNLIP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue, Primary antibody: CSB-PA132878(PNLIP Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second
  • 其他：

产品详情

  • Uniprot No.：
    P16233
  • 基因名：
    PNLIP
  • 别名：
    lipase, pancreatic antibody; LIPP_HUMAN antibody; Pancreatic lipase antibody; Pancreatic triacylglycerol lipase antibody; PL antibody; PNLIP antibody; PNLIPD antibody; PTL antibody; Triacylglycerol acylhydrolase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human PNLIP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
  • 基因功能参考文献：
    1. Serum lipase subtype analysis cannot replace the standard lipase measurement for the diagnosis of acute pancreatitis, but the test demonstrated adequate sensitivity for use in triage or as an add-on test for serum lipase elevation. PMID: 27243230
    2. Presence of methionine at position 221 in the PNLIP protein sequence causes protein misfolding and aggregation. PMID: 25862608
    3. All these findings support the use of YLLIP2 in enzyme replacement therapy for the treatment of pancreatic exocrine insufficiency, a pathological situation in which an acidification of intestinal contents occurs. PMID: 24650780
    4. In patients with intraductal papillary mucinous neoplasm without a history of pancreatitis, serum pancreatic lipase and amylase outside normal range are associated with risk of malignancy. PMID: 25239347
    5. a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency PMID: 24262094
    6. Low PNLIP expression is associated with pancreatic cancer. PMID: 23918603
    7. Triacylglycerol lipase and alpha-amylase are highly over-expressed in pancreatic cyst fluids in patients with mucinous pancreatic neoplasms. PMID: 22393262
    8. Combination of two mutations with a promising one at the entrance of the catalytic cavity (K80E) negatively affected the lipase activity at neutral pH but not that at acidic pH. PMID: 20150178
    9. the amplitude of the lid opening measured in solution or in a frozen solution in the presence of amphiphiles PMID: 20136147
    10. Review. The structure and function of the pancreatic lipase C2 domains, based on the recent 3D structures and improved sequence alignments are reviewed. PMID: 12369922
    11. analysis of human pancreatic lipase from pancreatic juice (BCR693) and a recombinant form (BCR694) PMID: 12667003
    12. examination of tryptophan changes in pancreatic lipase PMID: 14580194
    13. a specific method of measuring classical pancreatic lipase in human serum PMID: 15316225
    14. analysis of a lid hydrophobicity pattern in pancreatic lipase PMID: 16179352
    15. pancreatic lipase-colipase interactions in the presence of bile salt micelles are mediated by Val-407 and Ile-408 of PL PMID: 16431912
    16. Electron paramagnetic resonance spectroscopy along with site-directed spin labeling was used to monitor the conformational changes in the human PL lid in solution to assess the effects of partners of the lipase, i.e. colipase and bile salts. PMID: 17269661
    17. Introducing a negative charge close to the catalytic histidine induced a shift of the pH optimum toward acidic values but strongly reduced the lipase activity. PMID: 18353248
    18. The disulfide bridge between the hinges of the lid kept the secondary structure of the lid intact, whereas the HPL was completely unfolded. PMID: 19113953
    19. Trp-107 and Trp-253 contribute to the change in steady state fluorescence that is triggered by mixed micelles of inhibitor and bile salt. PMID: 19346257

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  • 相关疾病：
    Pancreatic lipase deficiency (PNLIPD)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    AB hydrolase superfamily, Lipase family
  • 数据库链接：

    HGNC: 9155

    OMIM: 246600

    KEGG: hsa:5406

    STRING: 9606.ENSP00000358223

    UniGene: Hs.501135