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PNCK Antibody

  • 货号：
    CSB-PA018259GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6P2M8
  • 基因名：
    PNCK
  • 别名：
    Calcium/calmodulin dependent protein kinase type 1B antibody; Calcium/calmodulin-dependent protein kinase type 1B antibody; CaM KI beta antibody; CaM kinase I beta antibody; CaM kinase IB antibody; CaM-KI beta antibody; CaMK1b antibody; CaMKI beta antibody; CaMKI-beta antibody; EC 2.7.11.17 antibody; KCC1B_HUMAN antibody; MGC45419 antibody; PNCK antibody; Pregnancy up regulated non ubiquitously expressed CaM kinase antibody; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PNCK
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1.
  • 基因功能参考文献：
    1. Pnck may be a marker of Trastuzumab resistance and possibly a therapeutic target in breast cancer. PMID: 25773930
    2. the relationship between PNCK and prognosis in clear cell renal cell carcinoma PMID: 23634203
    3. Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck. PMID: 21325639
    4. Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis. PMID: 18562482
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 数据库链接：

    HGNC: 13415

    OMIM: 300680

    KEGG: hsa:139728

    STRING: 9606.ENSP00000405950

    UniGene: Hs.436667