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PMM1 Antibody

  • 货号：
    CSB-PA018237LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PMM1 antibody at 2µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: NIH/3T3 whole cell lysate
      Lane 3: 293T whole cell lysate
      Lane 4: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA018237LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PMM1 Polyclonal antibody
  • Uniprot No.：
    Q92871
  • 基因名：
    PMM1
  • 别名：
    Brain glucose-1,6-bisphosphatase antibody; Phosphomannomutase 1 antibody; PMM 1 antibody; pmm1 antibody; PMM1_HUMAN antibody; PMMH 22 antibody; PMMH-22 antibody; PMMH22 antibody; Sec53 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Phosphomannomutase 1 protein (2-262AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PMM1 Antibody (CSB-PA018237LA01HU)，的标记方式是Non-conjugated。对于PMM1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018237LB01HU PMM1 Antibody, HRP conjugated ELISA
    FITC CSB-PA018237LC01HU PMM1 Antibody, FITC conjugated
    Biotin CSB-PA018237LD01HU PMM1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
  • 基因功能参考文献：
    1. a triple mutant of phospomannomutase1 that retains mutase and phosphatase activity, but is unable to bind inosine monophosphate, was characterized. PMID: 29261720
    2. Mutations in phosphomannomutase is associated with ophthalmic manifestations of congenital disorder of glycosylation type 1a PMID: 12789572
    3. human alpha-phosphomannomutase 1 crystallographic structure reveals the structural basis of congenital disorder of glycosylation type 1a PMID: 16540464
    4. analysis of mental development in a patient with phosphomannomutase deficiency who is compound heterozygous for T237R/C241S mutations [case report] PMID: 17186415
    5. The genes GUS and PMM1 are recommended for normalization purposes in gene expression studies of liver tissue from patients with chronic hepatitis. PMID: 18591914
    6. PMM1 is responsible for the degradation of Glc-1,6-P(2) in brain PMID: 18927083

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Eukaryotic PMM family
  • 组织特异性：
    Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
  • 数据库链接：

    HGNC: 9114

    OMIM: 601786

    KEGG: hsa:5372

    STRING: 9606.ENSP00000216259

    UniGene: Hs.75835