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PMEPA1 Antibody

  • 货号：
    CSB-PA628756
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of 823 22RV1 HELA HEPG2 Cell Lysate, antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
  • 其他：

产品详情

  • Uniprot No.：
    Q969W9
  • 基因名：
    PMEPA1
  • 别名：
    PMEPA_HUMAN antibody; PMEPA1 antibody; Prostate transmembrane protein; androgen induced 1 antibody; Solid tumor associated 1 protein antibody; Solid tumor-associated 1 protein antibody; STAG1 antibody; TMEPAI antibody; Transmembrane prostate androgen induced protein antibody; Transmembrane prostate androgen-induced protein antibody; Transmembrane; prostate androgen induced RNA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 1268-1341
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000-1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
  • 基因功能参考文献：
    1. JHY-A007-50 mediates the downregulation of TMEPAI expression. PMID: 30069967
    2. describe recent progresses in the understanding of how the TMEPAI family physiologically contributes to cellular functions and diseases PMID: 29945215
    3. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
    4. study showed that the inhibition of autophagy induced by the depletion of TMEPAI is involved in regulation of Beclin-1. PMID: 27163528
    5. these findings indicated that PMEPA1 participates in TGF-beta- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression. PMID: 27697531
    6. the present study suggest that the upregulation of miR19a3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression. PMID: 27035427
    7. Sp1 up-regulated TMEPAI protein expression, as well as Sp1 promoting TMEPAI-induced cell proliferation. PMID: 27625141
    8. PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. PMID: 26758191
    9. these data elaborated on the diverse activity among TCF/LEF family members with respect to the transcriptional regulation of the TMEPAI gene. PMID: 26590303
    10. Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells. PMID: 26927372
    11. Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR) through NEDD4 ubiquitin protein ligase and PTEN protein. PMID: 25883222
    12. Downregulation of PMEPA1 may result in increased androgen receptor protein levels and function in cancer of the prostate cells, contributing to prostate tumorigenesis. PMID: 24694733
    13. EGF signaling collaboratively regulates TGF-beta-induced TMEPAI expression. PMID: 25482449
    14. TMEPAI is translocated on the lysosome and late endosome, and that association with Nedd4 is required for the transport of TMEPAI to the lysosome. PMID: 24933703
    15. TMEPAI promotes tumorigenic activities in lung cancer cells. PMID: 24438557
    16. The levels of TMEPAI in lung tumor tissues are very high. PMID: 23615405
    17. Differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. PMID: 17318295
    18. Results suggest that TMEPAI functions in breast cancer as a molecular switch that converts TGF-beta from a tumor suppressor to a tumor promoter. PMID: 20610632
    19. Expression of PMEPA1 was well maintained both in colon cancer primary tumors and in colon cancer liver metastases. PMID: 12670906
    20. PMEPA1 negatively regulates growth of androgen responsive or refractory prostate cancer cells, and these functions may be mediated through the interaction of PMEPA1 with the NEDD4 protein. PMID: 12907594
    21. DNA methylation within the PMEPA1 promoter downstream sequences suggests that methylation of SP1 binding sites may also contribute to the repression of PMEPA1 gene PMID: 18174752
    22. decreased PMEPA1 expression frequently noted in prostate cancers may lead to increased AR functions and strengthen the biological role of the NEDD4-binding protein PMEPA1 in prostate cancers PMID: 18703514

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  • 亚细胞定位：
    Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
  • 蛋白家族：
    PMEPA1 family
  • 组织特异性：
    Highest expression in prostate. Also expressed in ovary.
  • 数据库链接：

    HGNC: 14107

    OMIM: 606564

    KEGG: hsa:56937

    STRING: 9606.ENSP00000345826

    UniGene: Hs.517155