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PLXND1 Antibody

  • 货号：
    CSB-PA118655
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA118655(PLXND1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA118655(PLXND1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y4D7
  • 基因名：
    PLXND1
  • 别名：
    KIAA0620 antibody; MGC75353 antibody; PLEX D1 antibody; PLEXD 1 antibody; PLEXD1 antibody; Plexin-D1 antibody; PlexinD1 antibody; PLXD1_HUMAN antibody; PLXN D1 antibody; PLXND 1 antibody; PLXND1 antibody; PLXND1 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human PLXND1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E.
  • 基因功能参考文献：
    1. the receptor Plexin-D1 contains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes. PMID: 28224988
    2. SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM. PMID: 28554271
    3. s found that the PlexinD1 cleavage product binds to actin rods, pathological aggregate-like structures which had so far been described for age-related neurodegenerative diseases. Data suggest a novel disease mechanism for SMA involving formation of actin rods as a molecular sink for a cleaved PlexinD1 fragment leading to dysregulation of receptor signaling. PMID: 29016853
    4. Plexin D1 plays a role in collagen contraction in human lung fibroblasts. PMID: 26648031
    5. Findings suggest that Plexin-D1/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc) endothelium. PMID: 26292963
    6. finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS patients suggests that de novo mutations in other genes might account for other MBS patients PMID: 26068067
    7. The data indicate that Plexin-D1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type. PMID: 25976775
    8. Plxnd1 is a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans PMID: 25831505
    9. The identification and characterization of SH3BP1 as a novel downstream effector of Sema3E-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior. PMID: 24841563
    10. It is therefore suggested that SEMA3C signaling, propagated through the heterodimer receptor plexin-D1/neuropilin, is important for truncus arteriosus septation PMID: 24254849
    11. A critical role of Sema3E/Plexin D1 interaction in tumor resistance to apoptosis. PMID: 24139859
    12. Strong expression of plexD1 was detected in endothelial cells of cervical cancer samples, yet no expression was seen in endothelial cells of normal cervical tissues, which suggests a potential role of PlexD1 in cervical cancer-associated angiogenesis PMID: 22738647
    13. analysis of Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer PMID: 21559368
    14. a novel phospholipid-regulated antiangiogenic signaling pathway whereby Sema3E activates Arf6 through Plexin-D1 and consequently controls integrin-mediated endothelial cell attachment to the extracellular matrix and migration. PMID: 21795701
    15. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice PMID: 21505259
    16. Semaphorin 3E-Plexin D1 signaling in cancer cells is crucially implicated in their metastatic behavior and may therefore be a promising target for strategies aimed at blocking tumor metastasis. PMID: 20664171
    17. Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. PMID: 20385769
    18. Results of extensive mutational analysis leads to the exclusion of the PLEXIN-D1 gene as the causative gene in Mobius syndrome 2, and in isolated Mobius syndrome. PMID: 15301830
    19. These results show that PLXND1 expression during tumor development is strongly correlated with both invasive behavior and metastasis, but exclude Sema3E as an activating ligand. PMID: 18974298
    20. Plexin D1 is abundantly expressed on tumor vasculature and malignant cells in the primary and metastatic tumors. PMID: 19703316

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  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein. Cell projection, lamellipodium membrane.
  • 蛋白家族：
    Plexin family
  • 组织特异性：
    Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 9107

    OMIM: 604282

    KEGG: hsa:23129

    STRING: 9606.ENSP00000317128

    UniGene: Hs.301685