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PLVAP Antibody

  • 货号：
    CSB-PA018214GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BX97
  • 基因名：
    PLVAP
  • 别名：
    FELS antibody; Fenestrated endothelial linked structure protein antibody; Fenestrated endothelial-linked structure protein antibody; gp68 antibody; Hypothetical protein DKFZp667O074 antibody; Meca 32 antigen antibody; MECA32 antigen antibody; Panendothelial cell antigen antibody; Plasmalemma vesicle associated protein antibody; Plasmalemma vesicle protein 1 antibody; Plasmalemma vesicle-associated protein antibody; Plvap antibody; PLVAP_HUMAN antibody; PV 1 antibody; PV-1 antibody; PV1 antibody; PV1 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human PLVAP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
  • 基因功能参考文献：
    1. PV-1 transcription was markedly induced in diabetic retina and by VEGF in retinal endothelial cells PMID: 19284967
    2. Expression of plasmalemma vesicle-associated protein (PLVAP) is increased in endothelial cells in the presence of VEGF PMID: 22200486
    3. In Kimba and Akimba mice fluorescein leakage was associated with focal angiogenesis and correlated significantly with Plvap gene expression. PMID: 24703908
    4. Plasmalemma vesicle-associated protein has a role in vascular permeability PMID: 26878208
    5. The molecule recognized by PAL-E and anti-PV-1 antibodies is not NRP-1 but PV-1. PMID: 22627768
    6. These results suggest that PV1 protein is able to block SV40 infectivity at low but not at high viral concentration either by interfering with the infective internalization pathway at the cell surface or at a post internalization step. PMID: 21827737
    7. Case Report: Suggest activated platelets, enhanced coagulation state, glomerular expression of PV-1 and endothelial damage may contribute to glomerulonephropathy associated with polycythemia vera. PMID: 20979949
    8. PV1 is a key structural component, necessary for the biogenesis of the stomatal and fenestral diaphragms. PMID: 15155804
    9. Plasmalemmal vesicle associated protein-1 has a role in brain tumor angiogenesis PMID: 16278383
    10. leukocyte transendothelial migration is the first known function for PV-1 PMID: 19420356

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.
  • 数据库链接：

    HGNC: 13635

    OMIM: 607647

    KEGG: hsa:83483

    STRING: 9606.ENSP00000252590

    UniGene: Hs.107125