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PLP2 Antibody

  • 中文名称：
    PLP2兔多克隆抗体
  • 货号：
    CSB-PA018203GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q04941
  • 基因名：
    PLP2
  • 别名：
    PLP2 antibody; A4 antibody; Proteolipid protein 2 antibody; Differentiation-dependent protein A4 antibody; Intestinal membrane A4 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PLP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in cell differentiation in the intestinal epithelium.
  • 基因功能参考文献：
    1. PLP2 specifically binds to phosphatidylinositol 3 kinase to activate the protein kinase B pathway to enhance cell proliferation, adhesion, and invasion in melanoma cells. PMID: 26287415
    2. miR-664 negatively regulates PLP2 and promotes proliferation and invasion of T-ALL cell lines. Thus, miR-664 may represent a potential therapeutic target for T-ALL intervention. PMID: 25735976
    3. PLP2 and RAB5C are binding partners of TPD52. PMID: 24604726
    4. This work ascribes a critical function to PLP2 for viral ligase activity and underlines the power of non-lethal haploid genetic screens in human cells to identify the genes involved in pathogen manipulation of the host immune system. PMID: 24278019
    5. PLP2/A4 has a role in the chemotactic processes via CCR1 PMID: 15474493
    6. PLP2 is expressed abundantly in the pyramidal cells of hippocampus and granular cells of the cerebellum in the brains of a cohort of males with probable X-linked mental retardation. PMID: 17416750

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 组织特异性：
    Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.
  • 数据库链接：

    HGNC: 9087

    OMIM: 300112

    KEGG: hsa:5355

    STRING: 9606.ENSP00000365505

    UniGene: Hs.77422