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PLEKHF2 Antibody

  • 货号：
    CSB-PA884492ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA884492ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PLEKHF2 Polyclonal antibody
  • Uniprot No.：
    Q9H8W4
  • 基因名：
  • 别名：
    110070J07Rik antibody; AA673237 antibody; FLJ13187 antibody; PH and FYVE domain containing protein 2 antibody; PH and FYVE domain-containing protein 2 antibody; PH domain containing family F member 2 antibody; PH domain-containing family F member 2 antibody; Phafin 2 antibody; Phafin-2 antibody; PHAFIN2 antibody; PKHF2_HUMAN antibody; pleckstrin homology domain containing, family F (with FYVE domain) member 2 antibody; pleckstrin homology domain containing, family F (with FYVE domain) member2 antibody; Pleckstrin homology domain-containing family F member 2 antibody; Plekhf2 antibody; ZFYVE18 antibody; Zinc finger FYVE domain containing protein 18 antibody; Zinc finger FYVE domain-containing protein 18 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pleckstrin homology domain-containing family F member 2 protein (1-249AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
  • 基因功能参考文献：
    1. PtdIns(3)P binding to Phafin2 occurs with high affinity, triggering minor conformational changes in the protein. Taken together, these studies represent a platform for establishing the structural basis of Phafin2 molecular interactions and the role of the two potentially redundant PtdIns(3)P-binding domains of the protein in endomembrane compartments. PMID: 28152563
    2. These findings establish that lysosomal accumulation of Akt and Phafin2 is a critical step in the induction of autophagy via an interaction with phosphatidylinositol 3 phosphate. PMID: 24416124
    3. Phafin2 controls EGFR trafficking through early endosomes by facilitating endosome fusion in concert with EEA1. PMID: 22816767
    4. These results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells' responses to the extracellular cues. PMID: 19995552
    5. Results demonstrate that EAPF/Phafin-2 facilitates TNF-alpha-induced cellular apoptosis through an ER-mitochondrial apoptotic pathway. PMID: 18288467

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  • 亚细胞定位：
    Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum.
  • 组织特异性：
    Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.
  • 数据库链接：

    HGNC: 20757

    OMIM: 615208

    KEGG: hsa:79666

    STRING: 9606.ENSP00000322373

    UniGene: Hs.29724