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PKIB Antibody

  • 中文名称：
    PKIB兔多克隆抗体
  • 货号：
    CSB-PA030218
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9C010
  • 基因名：
    PKIB
  • 别名：
    cAMP dependent protein kinase inhibitor 2 antibody; cAMP-dependent protein kinase inhibitor beta antibody; FLJ23817 antibody; IPKB_HUMAN antibody; OTTHUMP00000017115 antibody; OTTHUMP00000017116 antibody; OTTHUMP00000017117 antibody; PKI-beta antibody; PKIB antibody; PRKACN2 antibody; Protein kinase (cAMP dependent, catalytic) inhibitor beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PKI β.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
  • 基因功能参考文献：
    1. results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC PMID: 27325557
    2. mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription PMID: 24869658
    3. PKIB overexpression was strongly correlated with pAkt expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers. PMID: 23224602
    4. human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues PMID: 12061725
    5. PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma. PMID: 19035091
    6. Functional studies of the rat homolog PMID: 2052616
    7. Functional studies of the mouse homolog PMID: 7684369

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  • 蛋白家族：
    PKI family
  • 数据库链接：

    HGNC: 9018

    OMIM: 606914

    KEGG: hsa:5570

    UniGene: Hs.741340