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PITX1 Antibody

  • 货号：
    CSB-PA003791
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using Pitx1 Polyclonal Antibody
    • Western Blot analysis of Jurkat cells using Pitx1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P78337
  • 基因名：
    PITX1
  • 别名：
    BFT antibody; CCF antibody; Hindlimb expressed homeobox protein backfoot antibody; Hindlimb-expressed homeobox protein backfoot antibody; Homeobox protein PITX1 antibody; LBNBG antibody; Paired like homeodomain 1 antibody; Paired like homeodomain transcription factor 1 antibody; Paired-like homeodomain transcription factor 1 antibody; Pituitary homeo box 1 antibody; Pituitary homeobox 1 antibody; Pituitary otx related factor antibody; Pitx1 antibody; PITX1_HUMAN antibody; POTX antibody; PTX1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Pitx1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
  • 基因功能参考文献：
    1. PITX1 might serve as a potential biomarker for early detection and prognosis prediction of patients with lung adenocarcinoma. PMID: 30322808
    2. As a transcriptional activator, PITX1 regulates apoptosis-related genes, including PDCD5, during gastric carcinogenesis. PMID: 29734189
    3. we demonstrated a novel oncogenic mechanism of PTP1B on affecting PITX1/p120RasGAP in colorectal carcinoma(CRC). Regorafenib inhibited CRC survival through reserving PTP1B-dependant PITX1/p120RasGAP downregulation. PTP1B may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC PMID: 27752061
    4. Methylation status of PITX1 and even more so of lincRNA C5orf66-AS1 is a promising prognostic biomarker in HNSCC, in particular for HPV-negative patients. Further prospective evaluation is warranted PMID: 29425237
    5. role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes PMID: 27802335
    6. Our results suggest that mutation of a specific loop both affects the global G4 structure and impacts the ability to interact with a G4 binding protein and small molecule ligand. PMID: 28412358
    7. PITX1 expression may be involved in tumor progression and is a potential tumor suppressor gene and prognostic marker for cutaneous malignant melanoma. PMID: 27742032
    8. PTP1B dephosphorylates PITX1 to weaken its protein stability and the transcriptional activity for p120RasGAP gene expression PMID: 26840794
    9. To date, at least ten loci and four non-syndromic polydactyly-causing genes, including the GLI3 gene, the ZNF141 gene, the MIPOL1 gene and the PITX1 gene, have been identified. (Review) PMID: 26515020
    10. Low PITX1 expression is associated with lung metastasis in osteosarcoma. PMID: 25936343
    11. We discuss the genetic abnormality that causes Liebenberg syndrome, the genomic rearrangement at the PITX1 locus on chromosome 5. PMID: 23940102
    12. Down-regulation of PITX1 expression might contribute to the progression of cutaneous malignant melanoma via promoting cell proliferative activity PMID: 23816528
    13. PITX1 regulates HIF-1a activity by binding to HIF-1b and regulatingHIF recruitment to specific target promoters. PMID: 25558831
    14. DUX4 gene is activated in a small number of myonuclei, the DUX4 proteins diffuse to adjacent nuclei where they activate target genes such as PITX1. PMID: 23206257
    15. Lienberg syndrome results from a misexpression of PITX1 in upper extremities. PMID: 23395106
    16. A deletion in H2AFY gene and 190,428bp of its downstream region contains a regulatory sequence that suppresses the expression of PITX1 in the upper limb buds and causes Liebenberg syndrome. PMID: 23587911
    17. Identified two deletions and a translocation 5' of PITX1. PMID: 23022097
    18. High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas. PMID: 22438068
    19. mutations in PITX1 can cause a broad spectrum of isolated lower-limb malformations including clubfoot, deficiency of long bones, and mirror-image polydactyly. PMID: 22258522
    20. These studies identify PITX1 as a new ERalpha transcriptional target. PMID: 21868451
    21. leukemic activation of PITX1, a novice PRD-class homeobox gene in a subset of early-staged T-ALL, which may promote leukemogenesis by inhibiting T-cell development. PMID: 21425961
    22. Suggest that the PITX1 polymorphism (rs479632) is not a risk factor for knee ostoearthritis susceptibility in the Chinese Han population. PMID: 20054692
    23. PITX1 suppresses TERT transcription through direct binding to the TERT promoter, which ultimately regulates telomerase activity PMID: 21300782
    24. HOXA7, PIXT1 and PRRX1 homeobox genes have different patterns of expression in oral squamous cell carcinomas depending on its histological features. PMID: 21323949
    25. These findings provide evidence that c-Abl participates in modulating Pitx1 expression in the apoptotic response to DNA damage. PMID: 20563669
    26. SEDLIN is present in the nucleus, forms homodimers and that SEDT-associated mutations cause a loss of interaction with the transcription factors MBP1, PITX1 and SF1. PMID: 20498720
    27. the paired-like homeobox transcription factors Pitx1 and Pitx2 are factors functionally activating the proximal human prolactin promoter (hPRL-164luc) PMID: 12223489
    28. Modulation of interferon expression by co expression of hepatitis C virus NS5A protein and human homeodomain protein PTX1 PMID: 12620797
    29. this study represents the first demonstration for a role of pituitary homeobox 1 in the regulation of transcription of enzymes involved in adrenal steroidogenesis PMID: 12915995
    30. PITX1 mRNA expression is decreased in Barrett's esophagus, compared with matching normal squamous esophagus specimens, and is further decreased in Barrett's-associated cancer PMID: 16291394
    31. Pitx1 is expressed in normal human knee joint cartilage and its loss occurs in patients with knee osteoarthritis. PMID: 17549029
    32. p53 is a direct transcriptional target gene of hPitx1. This observation is concordant with the recent identification of hPitx1 as a tumor suppressor gene. PMID: 17762884
    33. up-regulation of both DUX4 and PITX1 in FSHD muscles may play critical roles in the molecular mechanisms of the disease PMID: 17984056
    34. Haplotype analys. within PITX1 showed overtransmission of the A-C haplotype of markers rs11959298 - rs6596189. Individuals homozygous for the A-C haplotype risk allele were 2.54 fold more likely to be autistic than indiv. who were not carrying the allele PMID: 18053270
    35. Down-regulation of PITX1 may be a frequent molecular event in gastric carcinogenesis; Aberrant levels of PITX1 expression may be closely correlated with the progression and differentiation of gastric cancer PMID: 18186570
    36. Asymmetric lower-limb malformations in individuals with homeobox PITX1 gene mutation are reported. PMID: 18950742
    37. High BFT expression is associated with non-small cell lung cancer. PMID: 19414376

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  • 相关疾病：
    Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly (CCF); Liebenberg syndrome (LBNBG)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 数据库链接：

    HGNC: 9004

    OMIM: 119800

    KEGG: hsa:5307

    STRING: 9606.ENSP00000265340

    UniGene: Hs.84136