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PIR Antibody

  • 货号：
    CSB-PA018032GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O00625
  • 基因名：
    PIR
  • 别名：
    3-dioxygenase PIR antibody; Iron binding nuclear protein antibody; Pir antibody; PIR_HUMAN antibody; Pirin antibody; Probable quercetin 2 antibody; probable quercetin 2,3-dioxygenase PIR antibody; Probable quercetinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PIR
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
  • 基因功能参考文献：
    1. Data suggest that only the Fe(III) form of pirin [not the Fe(II) form] enhances affinity of binding between p65 and DNA in the pirin-p65-DNA supramolecular complex. (pirin = quercetin 2,3-dioxygenase; p65 = RELA proto-oncogene NF-kappaB subunit) PMID: 28825294
    2. Pirin regulates E-cadherin independently of Bcl3-Slug signaling. PMID: 25680527
    3. The NRF2 transcription factor binds to this element in vivo and drives the basal PIR expression. PMID: 24390086
    4. Pirin is a newly identified binding partner of EAF2/U19 capable of down-regulating EAF2/U19 protein and alleviating its inhibition of prostate cancer cell survival/proliferation. PMID: 24272884
    5. Data indicate that the R-shaped area composes the interface for pirin-NF-kappaB binding that is responsible for modulation of NF-kappaB's DNA-binding properties. PMID: 23716661
    6. pirin may have a relevant role in melanoma progression. PMID: 21514450
    7. knockdown of pirin or treatment with the small molecule inhibited melanoma cell migration PMID: 20711196
    8. This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on bone mineral density and osteoporotic risk. PMID: 19766747
    9. An abnormal pattern of PIR sub-cellular localization is a characteristic feature of a subset of melanomas, and suggest it may represent a marker associated with disease progression. PMID: 20089166
    10. Pirin downregulation is a feature of acute myeloid leukemia and leads to impairment of terminal myeloid differentiation. PMID: 20010624
    11. x-ray crystallography of of human pirin shows that it is an iron-binding nuclear protein and transcription cofactor PMID: 14573596
    12. First report of enzymatic activity for any member of the Pirin family which may be an important connection to their roles in transcriptional regulation. PMID: 15951572

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Pirin family
  • 组织特异性：
    Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
  • 数据库链接：

    HGNC: 30048

    OMIM: 300931

    KEGG: hsa:8544

    STRING: 9606.ENSP00000369785

    UniGene: Hs.495728