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  4. PIP4K2A Antibody

PIP4K2A Antibody

  • 货号：
    CSB-PA049702
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA049702(PIP4K2A Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA049702(PIP4K2A Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, mouse brain tissue, Primary antibody: CSB-PA049702(PIP4K2A Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P48426
  • 基因名：
  • 别名：
    1 phosphatidylinositol 4 phosphate 5 kinase 2 alpha antibody; 1 phosphatidylinositol 4 phosphate 5 kinase antibody; 1 phosphatidylinositol 4 phosphate kinase antibody; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha antibody; 4 5 kinase B isoform antibody; 4 5 kinase C isoform antibody; 4 5 kinase isoform 2 alpha antibody; Diphosphoinositide kinase 2 alpha antibody; Diphosphoinositide kinase 2-alpha antibody; FLJ13267 antibody; Phosphatidylinositol 4 phosphate 5 kinase type 2 alpha antibody; Phosphatidylinositol 4 phosphate 5 kinase type II alpha antibody; Phosphatidylinositol-5-phosphate 4-kinase type II alpha antibody; Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha antibody; PI(5)P 4-kinase type II alpha antibody; PI42A_HUMAN antibody; PI5P4KA antibody; PIP4K2A antibody; PIP4KII-alpha antibody; PIP5K2 antibody; PIP5K2 alpha antibody; PIP5K2A antibody; PIP5KII alpha antibody; PIP5KII-alpha antibody; PIP5KIIA antibody; PIP5KIII antibody; PIPK antibody; PtdIns antibody; PtdIns(4)P-5-kinase B isoform antibody; PtdIns(4)P-5-kinase C isoform antibody; PtdIns(5)P-4-kinase isoform 2-alpha antibody; Type II phosphatidylinositol 4 phosphate 5 kinase 53 K isoform antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human PIP4K2A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level. In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress. Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
  • 基因功能参考文献：
    1. Recombinant PIP4K2A has the RNA binding activity and can associate specifically with Plasmodium 3'UTR RNAs. PMID: 29518392
    2. the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. PMID: 28476190
    3. meta-analysis of association of SNPs rs7088318 and rs4748793 and acute lymphoblastic leukemia susceptibility PMID: 27149463
    4. PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. PMID: 25548108
    5. The diplotype ATTGCT/ATTGCT of the PIP4K2A gene confers approximately three-times higher incomplete responsiveness towards antipsychotics in severely ill patients. PMID: 25025909
    6. PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML cells, and for the clonogenic potential of murine MLL-AF9 AML cells. PMID: 24681948
    7. We also showed that PIPKIIalpha silencing can induce alpha and gamma globin expression and decrease cell proliferation in K562 cells. PMID: 24788727
    8. Overexpression of type 2A PI(4)P5-kinase (PIP5K 2A) significantly reduced tamoxifen inhibition of Kv7.2/Kv7.3 and Kv7.2 R463Q channels. PMID: 24086693
    9. The data suggest that PI5P4Ka N251S does not significantly differ in activity from the wild-type enzyme, throwing a new light on its association with schizophrenia. PMID: 24081551
    10. Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 impaired growth on plastic and in xenografts. PMID: 24209622
    11. Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3) influences risk of acute lymphoblastic anemia and tumor subtype. (Meta-analysis) PMID: 23996088
    12. PIP5K2A variant influences susceptibility to schizophrenia in the Russian population of Siberia. s studied 355 patients with schizophrenic disorders from the Russian population of Siberia. PMID: 23739505
    13. The present study demonstrated that expression of PIP4K2A mRNA is significantly increased in LCL derived from patients with schizophrenia PMID: 21377334
    14. Studies indicate that the gene PIP5K2A was significantly elevated in stroma cells in distant metastasis group, compared to stroma in no distant metastasis group. PMID: 21124964
    15. PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha. PMID: 20583997
    16. A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A. PMID: 19937977
    17. study supports a minor role for PIP4K2A in schizophrenia etiology in the Irish population PMID: 19475563
    18. PIP5K2A is a novel signaling element in the regulation of EAAT3 activity PMID: 19644675
    19. translocation by protein kinase C is required for platelet alpha-granule secretion PMID: 12509423
    20. Single nucleotide polymorphism is associated with schizophfenia. PMID: 16801950
    21. The strongest evidence for schizophrenia association was found for the A-allele of SNP rs10828317 in the PIP5K2A gene, which was associated with both clinical subtypes. This SNP leads to a change in protein composition. PMID: 17410640
    22. PIP5K2A gene is implicated in schizophrenia in Chinese population PMID: 17555944
    23. rs11013052 was significantly associated with schizophrenia in this Indonesian family sample PMID: 18314871
    24. unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a PMID: 18364242
    25. We find that wild-type PIP5K2A but not the schizophrenia-associated mutant (N251S)-PIP5K2A activates heteromeric KCNQ2/KCNQ3 and KCNQ3/KCNQ5, the molecular correlate of neuronal M channels. PMID: 18545987
    26. PIP4KIIA may be one of the factors related to the regulation of the beta-globin gene expression and the different levels of Hb H in alpha-thalassemic patients PMID: 19656170

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  • 亚细胞定位：
    Cell membrane. Nucleus. Lysosome. Cytoplasm. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.
  • 组织特异性：
    Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine.
  • 数据库链接：

    HGNC: 8997

    OMIM: 603140

    KEGG: hsa:5305

    STRING: 9606.ENSP00000365757

    UniGene: Hs.57079