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  4. PIKFYVE Antibody

PIKFYVE Antibody

  • 货号：
    CSB-PA008032
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2I7
  • 基因名：
  • 别名：
    1 phosphatidylinositol 3 phosphate 5 kinase antibody; 1 phosphatidylinositol 4 phosphate 5 kinase antibody; 1-phosphatidylinositol 3-phosphate 5-kinase antibody; CFD antibody; epididymis luminal protein 37 antibody; FAB1 antibody; FAB1; S. cerevisiae; homolog of antibody; FYV1_HUMAN antibody; FYVE finger containing phosphoinositide kinase antibody; FYVE finger-containing phosphoinositide kinase antibody; KIAA0981 antibody; MGC40423 antibody; p235 antibody; Phosphatidylinositol 3 phosphate 5 kinase type III antibody; Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III antibody; Phosphatidylinositol 3-phosphate 5-kinase antibody; Phosphatidylinositol 3-phosphate 5-kinase type III antibody; Phosphatidylinositol 4 phosphate 5 kinase type III antibody; Phosphoinositide kinase; FYVE finger containing antibody; PIKfyve antibody; PIP5K antibody; PIP5K3 antibody; PIPkin III antibody; PIPkin-III antibody; PtdIns(4)P 5 kinase antibody; Type III PIP kinase antibody; ZFYVE29 antibody; Zinc finger; FYVE domain containing 29 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human PIP5KIII around the non-phosphorylation site of S307.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression. The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2). Also catalyzes the phosphorylation of p...显示更多
  • 基因功能参考文献：
    1. this study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase PMID: 28779020
    2. in PC-3 cells inhibition of PIKfyve by apilimod or depletion by siRNA increased the secretion of the exosomal fraction. PMID: 27438886
    3. A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity. PMID: 26934981
    4. A novel heterozygous frameshift mutation (c.3151dupA) and a copy number variations in PIKFYVE gene have been found in two unrelated Fleck corneal dystrophy patients. PMID: 26396486
    5. The PIKfyve complex is required for APP trafficking, suggesting a feedback loop in which APP, by binding to and stimulating phosphatidylinositol-3,5-bisphosphate vesicle formation may control its own trafficking. PMID: 26216398
    6. APP functionally cooperates with PIKfyve in vivo. This regulation is required for maintaining endosomal and neuronal function. PMID: 26125944
    7. data identify a novel role of the ArPIKfyve-Sac3 complex in the mechanisms controlling aggregate formation of Sph1 and suggest that Sac3 protein deficiency or overproduction may facilitate aggregation of aggregation-prone proteins PMID: 26405034
    8. Data suggest PIKFYVE, MTMR3 (myotubularin related protein 3) and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma. PMID: 24840251
    9. Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3, which is necessary and sufficient for suppression of type I IFN expression. PMID: 24600036
    10. Data indicate that AKT promotes EGFR recycling by phosphorylating and activating PIKfyve. PMID: 23757022
    11. the present observations show that PKB in conjunction with PIKfyve activates Kir2.1 channels. PMID: 23188060
    12. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. PMID: 23154468
    13. The results provide the first experimental evidence that the principal pathway for PtdIns5P intracellular production is through PIKfyve. PMID: 22621786
    14. A novel c.3060-3063 delCCTT (p.P968Vfs23) mutation in the PIKFYVE gene has been described in a five generation Greek family, which segregated with the fleck corneal dystrophy. PMID: 22065932
    15. The recent advances in Arf6/PIP5K signaling and its linkage to cellular functions, are reviewed. PMID: 20945365
    16. The first multicellular model for PIKFYVE loss, pointing to a role in lysosome maturation PMID: 16801682
    17. REVIEW : PIKFYVE and other phosphoinositides regulatory proteins are implicated in human genetic diseases PMID: 18429927
    18. A phylogenetic study revealing co-evolution of phosphoinositides kinases and phosphatases ; PIKFYVE is absent from several organisms and co-evolved with VAC14 and FIG4 PMID: 18774718
    19. Coexpression of PIKfyve is followed by a marked increase of glutamate induced currents in EAAT2 expressing oocytes. PMID: 19910676
    20. p40 interaction with PIKfyve p40 os demonstrated; PIKfyve interaction and the subsequent PIKfyve-catalyzed p40 phosphorylation anchor p40 to discrete membranes facilitating late endosome-to-TGN transport. PMID: 14530284
    21. PIKfyve selectively regulates the sorting and traffic of peripheral endosomes containing lysosomaly directed fluid phase cargo through controlling the morphogenesis and function of multivesicular bodies PMID: 14551253
    22. Linkage analysis localized CFD to a 24-cM (18-Mb) interval of chromosome 2q35 flanked by D2S2289 and D2S126 and containing PIP5K3. PMID: 15902656
    23. PIKfyve is distributed in microdomains that are distinct from those occupied by EEA1 and Hrs PMID: 16448788
    24. PIKfyve regulates endosome-to-TGN retrograde transport. PMID: 16954148
    25. results suggest that the local production of PtdIns(3)P implicates the fusion of macropinosomes via EEA1 as well as conventional early endosomes PMID: 17146146
    26. The observations disclose that PIKfyve participates in the SGK1-dependent regulation of SLC5A1. PMID: 17570343
    27. These data suggest for the first time a role of PtdIns5P and PIKfyve in oncogenesis, potentially linking intracellular trafficking to cancer. PMID: 18501703
    28. Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. PMID: 19056739
    29. PIKfyve is a potent stimulator of ClC-2-activity and contributes to SGK1-dependent regulation of ClC-2. PMID: 19232516
    30. Results suggest that PIKfyve inhibition may render the late endosome/lysosome compartment refractory to fusion with both autophagosomes and with EGFR-containing multivesicular bodies. PMID: 19582903
    31. PIKfyve-dependent channel degradation is essential to prevent Ca2+-induced toxicity in neurons. PMID: 19841139
    32. these results demonstrate that PIKfyve regulates CFTR activity, and suggest a novel mechanism of CFTR regulation. PMID: 19852935

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  • 相关疾病：
    Corneal dystrophy, fleck (CFD)
  • 亚细胞定位：
    Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein.
  • 数据库链接：

    HGNC: 23785

    OMIM: 121850

    KEGG: hsa:200576

    STRING: 9606.ENSP00000264380

    UniGene: Hs.744997