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PIK3R5 Antibody

  • 货号：
    CSB-PA008386
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8WYR1
  • 基因名：
  • 别名：
    5-bisphosphate 3-kinase regulatory subunit antibody; F730038I15Rik antibody; FOAP 2 antibody; FOAP2 antibody; OTTHUMP00000135339 antibody; p101 antibody; P101 PI3K antibody; p101-PI3K antibody; Phosphatidylinositol 4 antibody; Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibody; Phosphoinositide 3 kinase, regulatory subunit 5 antibody; Phosphoinositide 3 kinase, regulatory subunit 5, p101 antibody; Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibody; Phosphoinositide 3-kinase regulatory subunit 5 antibody; PI3 kinase p101 subunit antibody; PI3 kinase regulatory subunit 5 antibody; PI3-kinase p101 subunit antibody; PI3-kinase regulatory subunit 5 antibody; PI3R5_HUMAN antibody; PIK3 R5 antibody; PIK3R5 antibody; Protein FOAP 2 antibody; Protein FOAP-2 antibody; PtdIns 3 kinase p101 antibody; PtdIns 3 kinase regulatory subunit antibody; PtdIns-3-kinase p101 antibody; PtdIns-3-kinase regulatory subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PI 3-kinase p101.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
  • 基因功能参考文献：
    1. data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. PMID: 26173259
    2. PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
    3. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
    4. Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis. PMID: 22065524
    5. p101 has a role in membrane recruitment and activation of PI3K gamma PMID: 12507995
    6. analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma PMID: 15611065
    7. Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas PMID: 17486067

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  • 相关疾病：
    Ataxia-oculomotor apraxia 3 (AOA3)
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 组织特异性：
    Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
  • 数据库链接：

    HGNC: 30035

    OMIM: 611317

    KEGG: hsa:23533

    STRING: 9606.ENSP00000392812

    UniGene: Hs.278901