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PIK3CG Antibody

  • 货号：
    CSB-PA030057
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P48736
  • 基因名：
  • 别名：
    1 phosphatidylinositol 3 kinase antibody; 5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma antibody; 5-bisphosphate 3-kinase catalytic subunit gamma isoform antibody; p110 gamma antibody; p110gamma antibody; p120 PI3K antibody; p120-PI3K antibody; Phosphatidylinositol 3 kinase catalytic 110 kD gamma antibody; Phosphatidylinositol 3 kinase gamma, p110 gamma antibody; Phosphatidylinositol 3 kinase, catalytic, gamma polypeptide antibody; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit gamma antibody; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma antibody; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma isoform antibody; Phosphatidylinositol-4 antibody; Phosphoinositide 3 kinase catalytic gamma polypeptide antibody; Phosphoinositide 3 kinase gamma catalytic subunit antibody; PI 3 Kinase catalytic subunit gamma antibody; PI3 kinase p110 subunit gamma antibody; PI3-kinase subunit gamma antibody; PI3CG antibody; PI3K antibody; PI3K-gamma antibody; PI3Kgamma antibody; PIK3 antibody; Pik3cg antibody; PK3CG_HUMAN antibody; PtdIns-3-kinase subunit gamma antibody; PtdIns-3-kinase subunit p110-gamma antibody; Serine/threonine protein kinase PIK3CG antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PI 3-Kinase p110γ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
  • 基因功能参考文献：
    1. High PIK3CG expression correlates with low parasitism in human chagasic hearts. These data identify a previously unrecognized role of the canonical PI3Kgamma signaling pathway in the control of T. cruzi infection. PMID: 29666415
    2. PIK3CG gene rs12667819 was shown to be associated with attention-deficit/hyperactivity disorder (ADHD) risk in dominant model, ADHD-I type, and symptom scores. Gene-environmental interactions analysis revealed potential interactions of rs12667819 collaborating with blood lead and feeding style to modify ADHD risk. Expression quantitative trait loci analysis suggested that rs12667819 may mediate PIK3CG gene expression. PMID: 29097255
    3. Predicted activities were further evaluated through in-vitro testing of gallic acid and serpentine targeting PI3Kgamma. PMID: 28359246
    4. we propose that the PKA-Smurf1-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment. PMID: 28581524
    5. A positive correlation may exist between PIK3CG single nucleotide polymorphisms and patients with poor responsiveness to clopidogrel. PMID: 28885323
    6. PI3K, independently of protein kinase B, has a role in parasite-induced netosis. One of the main isoforms involved is PI3Kgamma which works in a reactive-oxygen-species-dependent way. PMID: 27154356
    7. Diminished expression of p110gamma in pulmonary vascular endothelial cells of patients with acute respiratory distress syndrome suggests that impaired p110gamma-FoxM1 vascular repair signaling is a critical factor in persistent leaky lung microvessels in ARDS. PMID: 26839042
    8. Findings suggest the pathophysiological role of phosphoinositide 3-kinase gamma (PI3Kgamma) in atherogenesis. PMID: 26658747
    9. Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity. PMID: 25753393
    10. findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type PMID: 26163264
    11. PI3Kgamma plays an important role in the development of eosinophilic inflammation a PMID: 24333185
    12. PI3Kgamma-induced VEGF expression was reduced when the human tocopherol-associated protein 1 (hTAP1/SEC14L2) was overexpressed suggesting formation of an inactive PI3Kgamma/hTAP1 heterodimer. PMID: 25290554
    13. data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. PMID: 26173259
    14. The interaction between PI3Kgamma and CNGA1 does not appear to play a role in regulation of CNG channel activity, but PI3Kgamma uses CNGA1 as an anchoring module to achieve close proximity to its substrate to generate D3-phosphoinositides PMID: 25644171
    15. Mfng is an oncogene acting through Notch-mediated induction of Pik3cg. PMID: 25808869
    16. increased susceptibility of individuals with COPD to influenza likely results from impaired antiviral responses, which are mediated by increased PI3K-p110alpha activity. PMID: 25751541
    17. Data indicate class of benzothiazoles as inhibitors of phosphoinositide 3-kinase gamma. PMID: 24754609
    18. phosphatidylinositol 3-kinase gamma has a role in insulin secretion induced by glucose-dependent insulinotropic polypeptide PMID: 25288806
    19. The data indicate that PI3Kgamma has a critical role in cAMP-mediated inflammatory hypernociception and analgesic signalling via mu-opioid receptors and PI3K/Akt in neuronal cells. PMID: 24654606
    20. Binding of the HSV-1 envelope initiates the epidermal growth factor receptor EGFR-PI3K signaling pathway, which leads to virus-induced early cofilin phosphorylation and F-actin polymerization. PMID: 24425731
    21. Ablating the interaction of PI3Kgamma with Gbetagamma heterodimers attenuates signaling, chemotaxis, and transformation driven by a GPCR agonist in cell lines. PMID: 24190998
    22. Class II enzyme PI3K-C2beta and class IB isozyme p110gamma mainly regulate the S1P- and high density lipoprotein (HDL)-dependent endothelial cell (EC) migration and PI3K-C2alpha primarily controls EC survival PMID: 23320105
    23. Assessed the expression of class I PI3K p110 isoforms in idiopathic pulmonary fibrosis lung tissue as well as in tissue-derived fibroblast cell lines. PMID: 23439433
    24. kinase-independent function of PI3Kgamma could directly inhibit GSK-3 function by preventing the PP2A-PPMT-1 interaction and that this inhibition of GSK-3 was independent of Akt. PMID: 23354687
    25. Upregulated phosphoinositide 3-kinase gamma is a target to suppress breast cancer cell migration and invasion. PMID: 23500535
    26. PI3Kgamma plays a key role in ipopolysaccharide-induced ROS generation in alveolar epithelial cells, thereby activating NF-kappaB PMID: 22825625
    27. Culturing spermatogonia in vitro at 37 degrees C could inhibit the expression of PI3K and c-kit, and lead to the mutation of the c-kit gene. PMID: 22568210
    28. The expression levels of PI3K protein and mRNA in esophageal squamous cell carcinoma tissues are significantly increased and PI3K plays a role in the carcinogenesis and development of ESCC. PMID: 22325219
    29. a novel mechanism that links PI3Kgamma activity with chemotaxis and superoxide production in G-protein coupled receptor signaling. PMID: 22573891
    30. PI3K might play a role in silica-induced DNA double strand break repair by regulating the expression levels of Ku70 and Ku80 in lung fibroblasts. PMID: 20465946
    31. findings suggest that PIK3CG function impacts the severity of the intraparenchymal bleed in patients with intracerebral hemorrhage PMID: 22449554
    32. role of p110gamma as a promoter of HCC proliferation and unveil an important cell cycle regulation function of this molecule. PMID: 21796621
    33. A novel regulatory role of p101 in the activation of PI3Kgamma. PMID: 22054284
    34. Ras-p110gamma interaction is necessary for efficient beta-selection-promoted proliferation but is dispensable for the survival or differentiation of thymocytes. PMID: 21930962
    35. protection from insulin resistance, metabolic inflammation, and fatty liver in mice lacking functional PI3Kgamma is largely consequent to their leaner phenotype PMID: 21949398
    36. Data show 5-HT can induce activation of two interrelated signaling pathways, Erk1/2 and PI3K/Akt to induce proliferation, migration, and differentiation. PMID: 19926313
    37. Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. PMID: 21707707
    38. Once activated, p110gamma promotes inside-out activation of a single integrin, alpha4beta1, causing myeloid cell invasion into tumors. PMID: 21665146
    39. PI3Kgamma, a PI3K isoform exhibiting restricted tissue distribution, is strictly required for signaling from the KSHV-encoded vGPCR oncogene to Akt/mTOR. PMID: 21665152
    40. Data demonstrate that AG/UAG attenuation of ISO-induced lipolysis involves PI3Kgamma/AKT and PDE3B. PMID: 21435395
    41. p110gamma anchors protein kinase A (PKA) through a site in its N-terminal region. Anchored PKA activates PDE3B to enhance cAMP degradation and phosphorylates p110gamma to inhibit PIP(3) production PMID: 21474070
    42. C. jejuni activates a PI3K/Akt-dependent anti-inflammatory pathway in human intestinal epithelial cells. PMID: 20863633
    43. Data indicate that stathmin is a target of the PI3K/Akt pathway in cervical cancer cells. PMID: 20657188
    44. Platelet migration was stimulated by SDF-1 through PI3 kinase dependent mechanism. PMID: 20852838
    45. This indicates that not only MAPK activation, but PI3Kgamma protein kinase activity in general is localized in the cytosol. PMID: 21185806
    46. Studies indicate that targeting the deregulated PI3K/PTEN-Akt signaling axis has currently emerged as one of the major tenets in anticancer drug development. PMID: 20622047
    47. PI3K-PDK1 signaling is essential for viability, MALT1 protease activity, and NF-kappaB activation in activated B-cell-like diffuse large B-cell lymphoma cells that carry mutations in the BCR proximal signaling adaptor CD79B. PMID: 21173233
    48. Data demonstrate that PI3K/Akt pathway regulates the expression of DNMT3B at transcriptional and post-transcriptional levels, which is particularly important to understand the effects of PI3K/Akt and DNMT3B on hepatocarcinogenesis. PMID: 20506537
    49. Data show an in vitro link between phosphoinositide 3-kinase-mediated HOXA9/HOXA10 expression, and a drug-resistant, progenitor cell phenotype in MGMT-independent pediatric glioblastoma. PMID: 20935218
    50. Findings show that oncogenic factors activating the phosphoinositide 3-kinase/Akt pathway can regulate alternative splicing of Casp9 via a coordinated mechanism involving the phosphorylation of SRp30a. PMID: 21045158

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    PI3/PI4-kinase family
  • 组织特异性：
    Pancreas, skeletal muscle, liver and heart.
  • 数据库链接：

    HGNC: 8978

    OMIM: 601232

    KEGG: hsa:5294

    STRING: 9606.ENSP00000352121

    UniGene: Hs.32942