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PIH1D1 Antibody

  • 货号：
    CSB-PA017991GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NWS0
  • 基因名：
    PIH1D1
  • 别名：
    NOP17 antibody; Nucleolar protein 17 homolog antibody; PIH1 domain containing 1 antibody; PIH1 domain containing protein 1 antibody; PIH1 domain-containing protein 1 antibody; PIH1D1 antibody; PIHD1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PIH1D1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
  • 基因功能参考文献：
    1. We propose that protein complexes assembled by the R2TP complex are defined by phosphorylation of a specific motif and recognition by the PIH1D1 subunit PMID: 24656813
    2. PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. PMID: 24036451
    3. Human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes. PMID: 22368283
    4. this study investigated the interaction between RPAP3 and PIH1D1. PMID: 23159623
    5. PIH1D1 may stabilize SNF5 by attenuating its proteasome degradation pathway. PMID: 20078948
    6. These results suggest that PIH1D1 may also function as a novel modulator of apoptosis pathway. PMID: 21078300
    7. Is part of an RNA polymerase II-associated complex with possible chaperone activity. PMID: 19450687

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    PIH1 family
  • 组织特异性：
    Expressed at low levels in normal mammary epithelial cells (at protein level). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen
  • 数据库链接：

    HGNC: 26075

    OMIM: 611480

    KEGG: hsa:55011

    STRING: 9606.ENSP00000262265

    UniGene: Hs.5245