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  4. Recombinant Human PIH1 domain-containing protein 1 (PIH1D1)

Recombinant Human PIH1 domain-containing protein 1 (PIH1D1)

  • 中文名称：
    人PIH1D1重组蛋白
  • 货号：
    CSB-YP889130HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PIH1D1重组蛋白
  • 货号：
    CSB-EP889130HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PIH1D1重组蛋白
  • 货号：
    CSB-EP889130HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PIH1D1重组蛋白
  • 货号：
    CSB-BP889130HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PIH1D1重组蛋白
  • 货号：
    CSB-MP889130HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PIH1D1
  • Uniprot No.：
  • 别名：
    NOP17; Nucleolar protein 17 homolog; PIH1 domain containing 1; PIH1 domain containing protein 1; PIH1 domain-containing protein 1; PIH1D1; PIHD1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-290
  • 氨基酸序列
    MANPKLLGMG LSEAEAIGAD SARFEELLLQ ASKELQQAQT TRPESTQIQP QPGFCIKTNS SEGKVFINIC HSPSIPPPAD VTEEELLQML EEDQAGFRIP MSLGEPHAEL DAKGQGCTAY DVAVNSDFYR RMQNSDFLRE LVITIAREGL EDKYNLQLNP EWRMMKNRPF MGSISQQNIR SEQRPRIQEL GDLYTPAPGR AESGPEKPHL NLWLEAPDLL LAEVDLPKLD GALGLSLEIG ENRLVMGGPQ QLYHLDAYIP LQINSHESKA AFHRKRKQLM VAMPLLPVPS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
  • 基因功能参考文献：
    1. We propose that protein complexes assembled by the R2TP complex are defined by phosphorylation of a specific motif and recognition by the PIH1D1 subunit PMID: 24656813
    2. PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. PMID: 24036451
    3. Human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes. PMID: 22368283
    4. this study investigated the interaction between RPAP3 and PIH1D1. PMID: 23159623
    5. PIH1D1 may stabilize SNF5 by attenuating its proteasome degradation pathway. PMID: 20078948
    6. These results suggest that PIH1D1 may also function as a novel modulator of apoptosis pathway. PMID: 21078300
    7. Is part of an RNA polymerase II-associated complex with possible chaperone activity. PMID: 19450687

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    PIH1 family
  • 组织特异性：
    Expressed at low levels in normal mammary epithelial cells (at protein level). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen
  • 数据库链接：

    HGNC: 26075

    OMIM: 611480

    KEGG: hsa:55011

    STRING: 9606.ENSP00000262265

    UniGene: Hs.5245