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PIGM Antibody

  • 货号：
    CSB-PA017976GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H3S5
  • 基因名：
    PIGM
  • 别名：
    PIGM antibody; GPI mannosyltransferase 1 antibody; EC 2.4.1.- antibody; GPI mannosyltransferase I antibody; GPI-MT-I antibody; Phosphatidylinositol-glycan biosynthesis class M protein antibody; PIG-M antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PIGM
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
  • 基因功能参考文献：
    1. B cells but not red cells are glycosylphosphatidylinositol deficient in PIGM-associated inherited glycosylphosphatidylinositol deficiency, caused by a core promoter mutation that abrogates Sp1 binding. PMID: 25293775
    2. Studies indicate that mutations in PGM1 by exome sequencing cause hypoglycemia and liver abnormalities. PMID: 23329837
    3. Mutation substantially reduces transcription of PIGM and blocks mannosylation of glycosylphosphatidylinositol(GPI), leading to partial but severe deficiency of GPI. PMID: 16767100
  • 相关疾病：
    Glycosylphosphatidylinositol deficiency (GPID)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PIGM family
  • 数据库链接：

    HGNC: 18858

    OMIM: 610273

    KEGG: hsa:93183

    STRING: 9606.ENSP00000357069

    UniGene: Hs.552810