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PID1 Antibody

  • 货号：
    CSB-PA800096LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA800096LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA800096LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA800096LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PID1 Polyclonal antibody
  • Uniprot No.：
    Q7Z2X4
  • 基因名：
    PID1
  • 别名：
    5033414K04Rik antibody; Ab1 119 antibody; FLJ20701 antibody; HMFN2073 antibody; MGC90850 antibody; NYGGF4 antibody; OTTHUMP00000164248 antibody; OTTHUMP00000204185 antibody; P CLI1 antibody; P-CLI1 antibody; PCLI1 antibody; PCLI1_HUMAN antibody; Phosphotyrosine interaction domain containing 1 antibody; Phosphotyrosine interaction domain-containing protein 1 antibody; PID1 antibody; Protein NYGGF4 antibody; PTB containing; cubilin and LRP1 interacting protein antibody; PTB-containing; cubilin and LRP1-interacting protein antibody; RGD1560766 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PTB-containing, cubilin and LRP1-interacting protein (15-168AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PID1 Antibody (CSB-PA800096LA01HU)，的标记方式是Non-conjugated。对于PID1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA800096LB01HU PID1 Antibody, HRP conjugated ELISA
    FITC CSB-PA800096LC01HU PID1 Antibody, FITC conjugated
    Biotin CSB-PA800096LD01HU PID1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Increases proliferation of preadipocytes without affecting adipocytic differentiation.
  • 基因功能参考文献：
    1. Overall survival and radiation-free progression-free survival were longer in medulloblastoma patients whose tumors had higher PID1 mRNA levels. PMID: 24300787
    2. overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4-overexpressing adipocytes PMID: 23274913
    3. NYGGF4 plays a role in IR and its effects on IR could be reversed by metformin through activating IRS-1/PI3K/Akt and AMPK-PGC1-alpha pathways. PMID: 22968630
    4. NYGGF4 acts directly on the IRS1/PI3K/AKT insulin pathway to reduce glucose uptake and transport, impairs mitochondrial function and causes insulin resistance, and thus may be a useful therapeutic target for obesity-associated insulin resistance. PMID: 22284633
    5. Overexpression of NYGGF4 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of NYGGF4-induced insulin resistance. PMID: 20165904
    6. TNFA up-regulated the expression of NYGGF4 during preadipocyte differentiation. PMID: 20140872
    7. NYGGF4 over-expression impairs the insulin sensitivity of 3T3-L1 adipocytes through decreasing GLUT4 translocation and had no effects on the secretory function of adipocytes. PMID: 19849947
    8. A novel gene named NYGGF4, which was expressed at a higher level in obese subjects, was isolated and characterized and could play a role in cell growth and adipogenesis process PMID: 16815647
    9. Data show that NYGGF4 regulates the functions of IRS-1 and Akt, decreases GLUT4 translocation and reduces glucose uptake in response to insulin. PMID: 19079291
    10. Q7Z2X4 protein (PID1) identified as a cytosolic ligand of LRP1 in a trimeric complex with Cubilin. Q7Z2X4 named PCLI1 (PTB-containing, Cubilin and LRP1 Interacting protein 1) PMID: 17124247

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in subcutaneous fat, heart, skeletal muscle, brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte.
  • 数据库链接：

    HGNC: 26084

    OMIM: 612930

    KEGG: hsa:55022

    STRING: 9606.ENSP00000375907

    UniGene: Hs.745038