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PHF11 Antibody

  • 货号：
    CSB-PA017900ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017900ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017900ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PHF11 Polyclonal antibody
  • Uniprot No.：
    Q9UIL8
  • 基因名：
    PHF11
  • 别名：
    APY antibody; BCAP antibody; BRCA1 C-terminus-associated protein antibody; IgE responsiveness (atopic) antibody; IGEL antibody; IGER antibody; IGHER antibody; NY REN 34 antigen antibody; NY-REN-34 antibody; NYREN34 antibody; PHD finger protein 11 antibody; Phf11 antibody; PHF11_HUMAN antibody; Renal carcinoma antigen NY-REN-34 antibody; RP11-185C18.3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PHD finger protein 11 protein (1-292AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Positive regulator of Th1-type cytokine gene expression.
  • 基因功能参考文献：
    1. data suggest that BCAP exists as two isoforms with subtly different roles in inhibition of ciliogenesis. Both are required to prevent ciliogenesis and one additionally controls cilium length after ciliogenesis has completed. PMID: 28775150
    2. contributes to T-cell activation and viability PMID: 20421878
    3. the single nucleotide polymorphism rs1046295 of PHF11 modulates allele-specific binding by the octamer-binding transcription factor 1 PMID: 21320718
    4. PHF11 (PHD finger protein 11) is not a major candidate gene for asthma or eczema in Chinese children PMID: 20717939
    5. We were unable to confirm associations of single nucleotide polymorphisms of the positional candidates DPP10 and PHF11 with wheeze. Significant associations with reported and examined eczema were only observed for DPP10. PMID: 20085599
    6. rs1046295 and rs16659 associated with asthma susceptibility in a Han Chinese population PMID: 19672052
    7. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. PMID: 12754510
    8. Results provide some further support for the role of genetic variation in PHF11 in asthma susceptibility. PMID: 17702965
    9. PHF11 is a regulator of T(H)1-type cytokine gene expression PMID: 18405956
    10. PHF11 is unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in two independent populations. PMID: 19386584

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highly expressed in T and B-cells, as well as natural killer and mature dendritic cells. Expressed at higher levels in Th1 as compared to Th2 cells. Expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liv
  • 数据库链接：

    HGNC: 17024

    OMIM: 147050

    KEGG: hsa:51131

    STRING: 9606.ENSP00000367570

    UniGene: Hs.369039