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  4. PHF10 Antibody

PHF10 Antibody

  • 货号：
    CSB-PA017898LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PHF10 antibody at 8µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: 293T whole cell lysate
      Lane 3: A2780 whole cell lysate
      Lane 4: U251 whole cell lysate
      Lane 5: A549 whole cell lysate
      Lane 6: A375 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57, 56, 52 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017898LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017898LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA017898LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PHF10 Polyclonal antibody
  • Uniprot No.：
    Q8WUB8
  • 基因名：
    PHF10
  • 别名：
    BAF45a antibody; BRG1-associated factor 45a antibody; FLJ10975 antibody; MGC111009 antibody; PHD finger protein 10 antibody; PHD finger protein 10; isoform a antibody; PHD zinc finger protein XAP135 antibody; Phf10 antibody; PHF10_HUMAN antibody; XAP135 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PHD finger protein 10 protein (151-360AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PHF10 Antibody (CSB-PA017898LA01HU)，的标记方式是Non-conjugated。对于PHF10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017898LB01HU PHF10 Antibody, HRP conjugated ELISA
    FITC CSB-PA017898LC01HU PHF10 Antibody, FITC conjugated
    Biotin CSB-PA017898LD01HU PHF10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 基因功能参考文献：
    1. We studied the expression of S100A4 and the total PHF10 protein in some human cancer cell lines. We have found that, in the cell lines studied, the PHF10 expression is correlated with the S100A4 expression. PMID: 27193724
    2. Phosphorylation of PHF10 isoforms occurs while they are incorporated as a subunit of the PBAF complex, and therefore phosphorylation of PHF10 isoforms may play an essential role in regulation of PBAF complex's function and mechanism of action. PMID: 27239853
    3. The study demonstrates the existence of functionally different PBAF complexes in mammalian cell. It also provides an insight into the molecular structure and role of human PHF10/BAF45a and characterizes it as an essential PBAF subunit. PMID: 24763304
    4. PHF10 repressed caspase-3 expression and impaired the programmed cell death pathway in human gastric cancer at the transcriptional level. PMID: 20530714
    5. Data show that that PHF10 is required for cell growth. PMID: 20068294

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SAYP family
  • 数据库链接：

    HGNC: 18250

    OMIM: 613069

    KEGG: hsa:55274

    STRING: 9606.ENSP00000341805

    UniGene: Hs.435933