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PHC1 Antibody

  • 货号：
    CSB-PA017891HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017891HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PHC1 Polyclonal antibody
  • Uniprot No.：
    P78364
  • 基因名：
    PHC1
  • 别名：
    Early development regulatory protein 1 antibody; hPH1 antibody; mPH1 antibody; PH1 antibody; Phc1 antibody; PHC1_HUMAN antibody; Polyhomeotic-like protein 1 antibody; Rae28 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PHC1 Antibody (CSB-PA017891HA01HU)，的标记方式是Non-conjugated。对于PHC1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017891HB01HU PHC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA017891HC01HU PHC1 Antibody, FITC conjugated
    Biotin CSB-PA017891HD01HU PHC1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
  • 基因功能参考文献：
    1. These findings reveal several cellular defects in cells carrying the PHC1 mutation and highlight the role of chromatin remodeling in the pathogenesis of PM. PMID: 23418308
    2. PcG complex 1, involving Rae28 and Cdt1, supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin PMID: 18650381
  • 相关疾病：
    Microcephaly 11, primary, autosomal recessive (MCPH11)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 3182

    OMIM: 602978

    KEGG: hsa:1911

    STRING: 9606.ENSP00000251757

    UniGene: Hs.744902