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PHACTR4 Antibody

  • 货号：
    CSB-PA050104
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8IZ21
  • 基因名：
    PHACTR4
  • 别名：
    Phactr4 antibody; PHAR4_HUMAN antibody; Phosphatase and actin regulator 4 antibody; PRO2963 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PHACTR4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.
  • 基因功能参考文献：
    1. Data indicate that Phactr4 acts as a tumor suppressor that is deleted and mutant in several cancers. PMID: 23319639
    2. The s show that rat Phactr1 inhibits PP1 activity in vitro, and mouse Phactr4 coimmunoprecipitates with actin and PP1 in human cells. PMID: 15107502
  • 亚细胞定位：
    Cytoplasm. Cell projection, lamellipodium.
  • 蛋白家族：
    Phosphatase and actin regulator family
  • 数据库链接：

    HGNC: 25793

    OMIM: 608726

    KEGG: hsa:65979

    UniGene: Hs.225641