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PEG3 Antibody

  • 中文名称：
    PEG3兔多克隆抗体
  • 货号：
    CSB-PA022042
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from A549 cells, using PEG3 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PEG3 Polyclonal antibody
  • Uniprot No.：
    Q9GZU2
  • 基因名：
    PEG3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human PEG3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.
  • 基因功能参考文献：
    1. Data suggest that PEG3 is required for TFEB induction and nuclear translocation in a VEGFR2- and AMPK-dependent manner for decorin/decorin receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB = transcription factor EB; VEGFR2 = vascular endothelial growth factor receptor-2; AMPK = AMP-activated protein kinase) PMID: 28798237
    2. Peg3 transcriptionally modulates BECN1 activity. PMID: 28174297
    3. Data indicate that a set of cis-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain. PMID: 27104590
    4. In the current study, the s have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3. PMID: 27075691
    5. A resident population of resident smooth muscle progenitor cells expressing PW1 was identified in pulmonary hypertension-associated vascular remodeling. PMID: 26838788
    6. PW1/Peg3 function is essential for conferring proper mesoangioblast competence and it's level in human mesoangioblasts may serve as a biomarker to identify donor populations for therapeutic application in muscular dystrophies. PMID: 25751651
    7. The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion. PMID: 23936039
    8. Genetic translocations involving PEG3 gene is associated with mesenchymal hamartoma of the liver. PMID: 24120702
    9. we have unveiled a mechanism for a secreted proteoglycan in inducing Peg3, a master regulator of macroautophagy in endothelial cells PMID: 23798385
    10. Results show that a five percent increase in DNA methylation of PEG3 is associated with a 1.6-fold increase invasive cervical cancer (ICC) risk. PMID: 23418553
    11. None of the folate cycle genotypes in the mother or infant were related to the methylation of IGF2, PEG3, or LINE-1. PMID: 23151531
    12. PEG3 gene is imprinted, with preferential expression from the paternal allele in human placenta. PMID: 11331620
    13. mammalian imprinting utilizes Peg3/Pw1 to co-opt the Wnt pathway, thereby regulating development and glioma growth PMID: 20064927
    14. Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death PMID: 11943780
    15. These results support a model in which pEg3 contributes to the control of progression through mitosis by phosphorylation of the CDC25 phosphatases. PMID: 15908796
    16. Loss of PEG3 expression may be a frequent event in gynecologic cancers. Given the known role of PEG3 in p53-mediated apoptosis, it is possible that PEG3 functions as a tumor suppressor. PMID: 16023706
    17. These results suggest that pEg3 might play a role at the cell cortex during mitosis. PMID: 16159311
    18. Down-regulation of PEG3 due to loss of heterozygosity and promoter methylation is associated with ovarian cancers PMID: 18286529
    19. abnormal regulation of PEG3 is associated with several glioma subtypes and that it plays an important role in tumorigenesis. PMID: 19367087
    20. PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR), but the PEG3-CpG island is the only DMR that is conserved among these three species. PMID: 19397955

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the
  • 数据库链接：

    HGNC: 8826

    OMIM: 601483

    KEGG: hsa:5178

    STRING: 9606.ENSP00000326581

    UniGene: Hs.731875