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PEBP4 Antibody

  • 货号：
    CSB-PA857025LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA857025LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA857025LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PEBP4 Polyclonal antibody
  • Uniprot No.：
    Q96S96
  • 基因名：
    PEBP4
  • 别名：
    PEBP4 antibody; CORK1 antibody; UNQ1933/PRO4408 antibody; Phosphatidylethanolamine-binding protein 4 antibody; PEBP-4 antibody; hPEBP4 antibody; Protein cousin-of-RKIP 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Phosphatidylethanolamine-binding protein 4 protein (23-227AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PEBP4 Antibody (CSB-PA857025LA01HU)，的标记方式是Non-conjugated。对于PEBP4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA857025LB01HU PEBP4 Antibody, HRP conjugated ELISA
    FITC CSB-PA857025LC01HU PEBP4 Antibody, FITC conjugated
    Biotin CSB-PA857025LD01HU PEBP4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
  • 基因功能参考文献：
    1. PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway PMID: 28193908
    2. knockdown of PEBP4 inhibited hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells. PMID: 27261570
    3. this study suggested that PEBP4 might promote the progression of pancreatic ductal adenocarcinoma PMID: 26311050
    4. Increased expression of phosphatidylethanolamine-binding protein 4 strongly associates with gliomas grade. PMID: 26725095
    5. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation. PMID: 27033522
    6. Increased miR-15b expression in lung adenocarcinoma patients treated with cisplatin-based chemotherapy was correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis. PMID: 25721211
    7. concluded that hPEBP4, specifically expressed in rectal cancer cells, is associated with radioresistance of rectal cancer PMID: 24594691
    8. overexpression of PEBP4, which we show to be a target of miR-34a, reduces the sensitivity of lung cancer cells to cisplatin PMID: 25038915
    9. in human breast cancer hPEBP4 is a novel and clinically relevant metastasis accelerator gene PMID: 24276246
    10. Human PEBP4 expression correlates negatively with estrogen and progesterone receptors in endometrial carcinoma. PMID: 23818363
    11. hPEBP4 knockdown potentiated the chemosensitization of the rituximab in B-cell lymphoma cells by regulating the expression of Bcl-xl, Cycline E, p21(waf/cip1) and p53 and the activation of caspase-3 and caspase-9. PMID: 23451095
    12. the independent predictive values of hPEBP4 in response of rectal cancer to preoperative radiotherapy, are reported. PMID: 22801881
    13. PEBP4 enhanced cell proliferation and invasion ability and inhibited apoptosis. Decreased PEBP4 expression may play a role in the reduced invasion ability and increased apoptosis of the human non-small cell lung cancer cell line HCC827. PMID: 22983920
    14. PEBP4 over-expression may promote the invasion and metastasis of non-small cell lung cancer. PMID: 22076923
    15. The over-expression of PEBP4 protein may be related to the tumorigenesis, development, metastasis, and invasion of colorectal cancer. PMID: 22125029
    16. Data show that PEBP4 protein overexpression was associated with the occurrence, invasion, and metastasis of lung squamous cell carcinoma. PMID: 21887552
    17. hPEBP4 inhibits proteasome-dependent ERalpha degradation through the Src pathway. PMID: 20460377
    18. hPEBP4 promotes cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK, and PE externalization. PMID: 15302887
    19. Silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer. PMID: 16865237
    20. Data show that PEBP4 participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK. PMID: 19197339

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Phosphatidylethanolamine-binding protein family
  • 数据库链接：

    HGNC: 28319

    OMIM: 612473

    KEGG: hsa:157310

    STRING: 9606.ENSP00000256404

    UniGene: Hs.491242