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PDZRN3 Antibody

  • 货号：
    CSB-PA891797LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA891797LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA891797LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDZRN3 Polyclonal antibody
  • Uniprot No.：
    Q9UPQ7
  • 基因名：
    PDZRN3
  • 别名：
    E3 ubiquitin-protein ligase PDZRN3 antibody; KIAA1095 antibody; Ligand of Numb protein X 3 antibody; likely ortholog of mouse semaF cytoplasmic domain associated protein 3 antibody; LNX3 antibody; PDZ domain containing ring finger 3 antibody; PDZ domain-containing RING finger protein 3 antibody; Pdzrn3 antibody; Protein SEMACAP3 antibody; PZRN3_HUMAN antibody; SEMACAP3 antibody; Semaphorin cytoplasmic domain associated protein antibody; Semaphorin cytoplasmic domain-associated protein 3 antibody; SEMCAP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDZRN3 Antibody (CSB-PA891797LA01HU)，的标记方式是Non-conjugated。对于PDZRN3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA891797LB01HU PDZRN3 Antibody, HRP conjugated ELISA
    FITC CSB-PA891797LC01HU PDZRN3 Antibody, FITC conjugated
    Biotin CSB-PA891797LD01HU PDZRN3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
  • 基因功能参考文献：
    1. s show that HPV-16 and HPV-18 E6 can target PDZRN3 in a PDZ- and proteasome-dependent manner and provide a connection between the papillomavirus life cycle and differentiation-related STAT signaling. PMID: 25355882
    2. a novel partner of Kidins220/ARMS PMID: 22609016
    3. These results indicate that PDZRN3 plays an important role in negative feedback control of BMP-2-induced osteoblast differentiation in C2C12 cells through inhibition of Wnt3a-beta-catenin signaling. PMID: 20668165
  • 亚细胞定位：
    Cell junction, synapse. Cytoplasm.
  • 组织特异性：
    Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
  • 数据库链接：

    HGNC: 17704

    OMIM: 609729

    KEGG: hsa:23024

    STRING: 9606.ENSP00000263666

    UniGene: Hs.660347