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PDS5A Antibody

  • 货号：
    CSB-PA017742GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q29RF7
  • 基因名：
    PDS5A
  • 别名：
    Cell proliferation inducing protein 54 antibody; Cell proliferation-inducing gene 54 protein antibody; KIAA0648 antibody; PDS5; regulator of cohesion maintenance; homolog A (S. cerevisiae) antibody; PDS5A antibody; PDS5A_HUMAN antibody; PIG54 antibody; SCC-112 antibody; SCC112 antibody; Sister chromatid cohesion protein 112 antibody; Sister chromatid cohesion protein PDS5 homolog A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PDS5A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
  • 基因功能参考文献：
    1. These results provide the first evidence indicating a tumor suppressor role of SA1 in early colon carcinogenesis PMID: 27549371
    2. By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion. PMID: 26051894
    3. The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication. PMID: 21865657
    4. Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells. PMID: 21069257
    5. Findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation. PMID: 15019998
    6. SCC-112 improve cell proliferation and contributes to tumorigenesis by interacting with p63 and promoting cell cycling. PMID: 17846787

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    PDS5 family
  • 组织特异性：
    Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
  • 数据库链接：

    HGNC: 29088

    OMIM: 613200

    KEGG: hsa:23244

    STRING: 9606.ENSP00000303427

    UniGene: Hs.331431