PDP1 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) PDP1 Polyclonal antibody
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Uniprot No.:Q9P0J1
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基因名:PDP1
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别名:[Pyruvate dehydrogenase [acetyl transferring]] phosphatase 1; mitochondrial antibody; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1 antibody; FLJ32517 antibody; Gm1024 antibody; MGC119646 antibody; mitochondrial antibody; PDH antibody; PDP 1 antibody; PDP antibody; Pdp1 antibody; PDP1_HUMAN antibody; PDPC 1 antibody; PDPC antibody; PPM2C antibody; Protein phosphatase 2C antibody; protein phosphatase 2C; magnesium dependent; catalytic subunit antibody; Pyruvate dehydrogenase (Lipoamide) phosphatase phosphatase antibody; Pyruvate dehydrogenase phosphatase catalytic subunit 1 antibody; Pyruvate dehydrogenase phosphatase; catalytic subunit 1 antibody; RP23 203A12.1 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial protein (1-154AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,PDP1 Antibody (CSB-PA878946LA01HU),的标记方式是Non-conjugated。对于PDP1 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:500-1:1000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
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基因功能参考文献:
- High PDH expression is associated with glucose intolerance. PMID: 28148899
- YB-1 phosphorylation at Ser-102 is an important prerequisite for CCL5 promoter activation during macrophage differentiation PMID: 24962578
- the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
- Although 7 days of bed rest induced whole body glucose intolerance, exercise-induced PDH regulation in skeletal muscle was not changed, suggesting that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant individuals. PMID: 21680880
- catalytic subunit of PDP1 crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c = 216.1 A. PMID: 20208177
- pyruvate dehydrogenase phosphatase PDP1 is down-regulated in circulating lymphocytes of obese subjects because it is poorly sensitive to magnesium/calcium; this defect is attenuated when plasma insulin is greatly enhanced PMID: 15897476
- Lower accumulation of free ADP and AMP after the FAT-adapt trial may be responsible for the decreased glycogenolysis and PDH activation during sprinting. PMID: 16188909
- Functional characterization of the bovine counterpart. PMID: 8396421
- Functional characterization of the rat counterpart. PMID: 9651365
- In cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex, the PDP-activity was significantly reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts. PMID: 1327585
- In postmortem tissue samples, from male child with metabolic acidosis, PDK normally reduced PDH-activity in ATP-presence. Addition of Ca++ and Mg++ did not restored PDH-activity. The defect was attributed to a markedly reduced PDP-activity. PMID: 172850
收起更多
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相关疾病:Pyruvate dehydrogenase phosphatase deficiency (PDP deficiency)
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亚细胞定位:Mitochondrion matrix.
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蛋白家族:PP2C family
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数据库链接:
HGNC: 9279
OMIM: 605993
KEGG: hsa:54704
STRING: 9606.ENSP00000379503
UniGene: Hs.22265