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PDLIM4 Antibody

  • 货号：
    CSB-PA017735LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: PDLIM4 antibody at 6.1µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 36, 26 kDa
      Observed band size: 36 kDa
    • Immunoprecipitating PDLIM4 in K562 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA017735LA01HU in K562 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA017735LA01HU (6µg) + K562 whole cell lysate (500µg)
      Lane 3: K562 whole cell lysate (20µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDLIM4 Polyclonal antibody
  • Uniprot No.：
    P50479
  • 基因名：
    PDLIM4
  • 别名：
    Enigma homolog antibody; LIM domain protein antibody; LIM domain protein RIL antibody; LIM protein RIL antibody; PDLI4_HUMAN antibody; PDLIM 4 antibody; PDLIM4 antibody; PDZ and LIM domain 4 antibody; PDZ and LIM domain protein 4 antibody; Reversion induced LIM protein antibody; Reversion-induced LIM protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PDZ and LIM domain protein 4 protein (81-243AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDLIM4 Antibody (CSB-PA017735LA01HU)，的标记方式是Non-conjugated。对于PDLIM4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017735LB01HU PDLIM4 Antibody, HRP conjugated ELISA
    FITC CSB-PA017735LC01HU PDLIM4 Antibody, FITC conjugated
    Biotin CSB-PA017735LD01HU PDLIM4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons.; Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration.
  • 基因功能参考文献：
    1. Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival. PMID: 22695491
    2. Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein. PMID: 21636573
    3. RIL and its variant sequences may be an important determinant of osteoporosis PMID: 12908099
    4. Ril modulates actin stress fiber turnover and enhances the association with actinin and actins. PMID: 14729062
    5. Results showed that the hypermethylation of PDLIM4 gene could be used as a sensitive molecular tool in detection of prostate. PMID: 16489065
    6. RIL methylation is a marker of adverse prognosis independent of chromosome 5 and 7 deletions. PMID: 17332327
    7. several genes that are known to be regulated by DNA methylation were up-regulated dramatically by integrin alpha6beta4 expression, including S100A4, FST, PDLIM4, CAPG, and Nkx2.2. PMID: 19011242
    8. PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells. PMID: 19212833
    9. Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. PMID: 19307596

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome.; [Isoform 2]: Cytoplasm.
  • 组织特异性：
    [Isoform 2]: Found in brain.
  • 数据库链接：

    HGNC: 16501

    OMIM: 603422

    KEGG: hsa:8572

    STRING: 9606.ENSP00000253754

    UniGene: Hs.424312