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PDLIM3 Antibody

  • 货号：
    CSB-PA017734GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q53GG5
  • 基因名：
    PDLIM3
  • 别名：
    Actinin associated LIM protein antibody; Actinin-associated LIM protein antibody; Alpha actinin 2 associated LIM protein antibody; Alpha-actinin-2-associated LIM protein antibody; DKFZp686L0362 antibody; Enigma homolog antibody; PDLI3_HUMAN antibody; PDLIM 3 antibody; PDLIM3 antibody; PDZ and LIM domain 3 antibody; PDZ and LIM domain protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PDLIM3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the organization of actin filament arrays within muscle cells.
  • 基因功能参考文献：
    1. This study confirmed that PDLIM3 as genetic modifiers of age at onset of Alzheimer disease. PMID: 26214276
    2. two abnormal splicing events for actinin-associated LIM protein 3 (PDLIM3/ALP) and fibronectin 1 (FN1) in the skeletal muscles of myotonic dystrophy type 1 patients. PMID: 21549096
    3. mutations in PDLIM3 and MYPN are infrequent in hypertrophic cardiomyopathies PMID: 20801532
    4. ZASP-like motif in actinin-associated LIM protein is required for interaction with the alpha-actinin rod and for targeting to the muscle Z-line PMID: 15084604
    5. Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM. PMID: 17254821

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  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
  • 组织特异性：
    Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
  • 数据库链接：

    HGNC: 20767

    OMIM: 605889

    KEGG: hsa:27295

    STRING: 9606.ENSP00000284770

    UniGene: Hs.701364