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PDK3 Antibody

  • 货号：
    CSB-PA613585ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PDK3 antibody at 1.6µg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: RAW264.7 whole cell lysate
      Lane 3: A431 whole cell lysate
      Lane 4: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 47, 49 kDa
      Observed band size: 47 kDa
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA613585ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDK3 Polyclonal antibody
  • Uniprot No.：
    Q15120
  • 基因名：
    PDK3
  • 别名：
    [Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial antibody; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 antibody; CMTX6 antibody; GS1-358P8.4 antibody; mitochondrial antibody; PDK3 antibody; PDK3_HUMAN antibody; Pyruvate dehydrogenase kinase isoenzyme 3 antibody; Pyruvate dehydrogenase kinase isoform 3 antibody; Pyruvate dehydrogenase kinase isozyme 3 antibody; Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial protein (137-406AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
  • 基因功能参考文献：
    1. We have identified a p.R158H PDK3 mutation in a Korean X-linked dominant Charcot-Marie-Tooth type 6 family PMID: 26801680
    2. Reduced pyruvate flux due to R158H mutant PDK3-mediated hyper-phosphorylation of the pyruvate dehydrogenase complex is the underlying pathogenic cause of peripheral neuropathy in X-linked dominant Charcot-Marie-Tooth disease. PMID: 23297365
    3. Findings suggest the HIF-1/PDK3 bioenergetic pathway as a new target for therapeutic intervention in metastatic melanoma. PMID: 22865452
    4. analysis of residues in L2 and residues in the C-terminal region and the lipoyl-binding pocket of PDK3 which are critical determinants for the cross-talk between L2 and PDK3, which up-regulates PDK3 activity PMID: 16849321
    5. crystal structure of the asymmetric PDHK3/lipoyl domain 2 complex; data suggest that the asymmetric complex represents a physiological state in which binding of a single L2-domain activates one of the PDHK protomers while inactivating another PMID: 17532006
    6. Distinct structural mechanisms for inhibition of PDK3 by AZD7545, dichloroacetate, and radicol. PMID: 17683942
    7. increased PDK3 expression due to elevated HIF-1alpha in cancer cells may play critical roles in metabolic switch during cancer progression and chemoresistance in cancer therapy PMID: 18718909

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  • 相关疾病：
    Charcot-Marie-Tooth disease, X-linked dominant, 6 (CMTX6)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    PDK/BCKDK protein kinase family
  • 组织特异性：
    Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain.
  • 数据库链接：

    HGNC: 8811

    OMIM: 300905

    KEGG: hsa:5165

    STRING: 9606.ENSP00000387536

    UniGene: Hs.296031