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PDHA2 Antibody

  • 货号：
    CSB-PA017716ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PDHA2 antibody at 1.62 μg/ml
      Lane 1: Mouse gonadal tissue
      Lane 2: 293T whole cell lysate
      Lane 3: A549 whole cell lysate
      Lane 4: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43 kDa
      Observed band size: 43 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017716ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDHA2 Polyclonal antibody
  • Uniprot No.：
    P29803
  • 基因名：
  • 别名：
    PDHA2 antibody; PDHAL antibody; Pyruvate dehydrogenase E1 component subunit alpha antibody; testis-specific form antibody; mitochondrial antibody; EC 1.2.4.1 antibody; PDHE1-A type II antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial protein (119-388AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
  • 基因功能参考文献：
    1. Our results indicated that miR215p targeted PDHA1 to regulate a metabolic switch and cancer progression in gastric cancer, and reveal the potential role of the miR215p/PDHA1 axis in gastric cancer treatment PMID: 30226598
    2. Methylation of the PDHA2 coding region can inhibit gene transcription. PMID: 22675509
    3. it is the full demethylation of the CpG island located in the coding region that seems to play a crucial role upon PDHA2 gene transcription in testis. PMID: 20005141
  • 亚细胞定位：
    Mitochondrion matrix.
  • 组织特异性：
    Testis. Expressed in postmeiotic spermatogenic cells.
  • 数据库链接：

    HGNC: 8807

    OMIM: 179061

    KEGG: hsa:5161

    STRING: 9606.ENSP00000295266

    UniGene: Hs.131361