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PDF Antibody

  • 货号：
    CSB-PA872538LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate
      All lanes: PDF antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 28 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA872538LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDF Polyclonal antibody
  • Uniprot No.：
    Q9HBH1
  • 基因名：
    PDF
  • 别名：
    PDF antibody; PDF1A antibody; Peptide deformylase antibody; mitochondrial antibody; EC 3.5.1.88 antibody; Polypeptide deformylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Peptide deformylase, mitochondrial protein (16-143AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDF Antibody (CSB-PA872538LA01HU)，的标记方式是Non-conjugated。对于PDF Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872538LB01HU PDF Antibody, HRP conjugated ELISA
    FITC CSB-PA872538LC01HU PDF Antibody, FITC conjugated
    Biotin CSB-PA872538LD01HU PDF Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Removes the formyl group from the N-terminal Met of newly synthesized proteins.
  • 基因功能参考文献：
    1. compound M7594_0037 exhibited potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 35.26, 29.63 and 24.63 muM, respectively. Molecular docking studies suggested that M7594_0037 and its three derivatives could interact with Human peptide deformylase by several conserved hydrogen bonds. PMID: 27023495
    2. c-myc regulated the expression of human PDF. PMID: 24675470
    3. This is the first report showing that PDF is over-expressed in breast, colon, and lung cancers PMID: 23815882
    4. these data reveals that PDF has several transcription start sites, the most important of which only 18 bp from the initiation codon. PMID: 22554513
    5. the origin, evolution and preservation of the COG8/PDF same-strand overlap follow similar mechanistic steps as those documented for antisense overlaps where gain and/or loss of splice sites and polyadenylation signals seems to drive the process. PMID: 21805148
    6. The inhibition of HsPDF may provide an explanation for the mechanism by which actinonin is cytotoxic against various human tumor cell lines. PMID: 14637138
    7. Despite the lack of true S2' and S3' binding pockets, confirmed through peptide binding modeling, enzyme kinetics suggest a combined contribution from P2'and P3' positions of a formylated peptide substrate to turnover. PMID: 19236878

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Polypeptide deformylase family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 30012

    KEGG: hsa:64146

    STRING: 9606.ENSP00000288022

    UniGene: Hs.130849