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PDE6D Antibody

  • 货号：
    CSB-PA526126LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PDE6D antibody at 1.5µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 18 kDa
      Observed band size: 18 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA526126LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE6D Polyclonal antibody
  • Uniprot No.：
    O43924
  • 基因名：
    PDE6D
  • 别名：
    5''-cyclic phosphodiesterase subunit delta antibody; GMP PDE delta antibody; GMP-PDE delta antibody; p17 protein antibody; PDE 6 antibody; PDE 6D antibody; PDE D antibody; PDE6 antibody; PDE6D antibody; PDE6D_HUMAN antibody; PDED antibody; Phosphodiesterase 6D cGMP specific antibody; Phosphodiesterase 6D cGMP specific rod delta antibody; Protein p17 antibody; Retinal rod photoreceptor cGMP phosphodiesterase delta antibody; Retinal rod rhodopsin sensitive cGMP 3' 5' cyclic phosphodiesterase subunit delta antibody; Retinal rod rhodopsin-sensitive cGMP 3'' antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3\',5\'-cyclic phosphodiesterase subunit delta protein (1-150AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDE6D Antibody (CSB-PA526126LA01HU)，的标记方式是Non-conjugated。对于PDE6D Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA526126LB01HU PDE6D Antibody, HRP conjugated ELISA
    FITC CSB-PA526126LC01HU PDE6D Antibody, FITC conjugated
    Biotin CSB-PA526126LD01HU PDE6D Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

引用文献

产品评价

靶点详情

  • 功能：
    Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
  • 基因功能参考文献：
    1. PDE6delta binds selectively to the C-terminus of RPGR and that this interaction is critical for RPGR's localization to cilia. PMID: 28172980
    2. Studies indicate that the binding of UNC119 and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner. PMID: 27911709
    3. Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies. PMID: 24166846
    4. RPGR is acting as a scaffold protein recruiting cargo-loaded PDE6D and Arl3 to release lipidated cargo into cilia. PMID: 23559067
    5. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
    6. Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane. PMID: 22179043

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  • 相关疾病：
    Joubert syndrome 22 (JBTS22)
  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    PDE6D/unc-119 family
  • 组织特异性：
    Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
  • 数据库链接：

    HGNC: 8788

    OMIM: 602676

    KEGG: hsa:5147

    STRING: 9606.ENSP00000287600

    UniGene: Hs.516808