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PDE1C Antibody

  • 货号：
    CSB-PA623901LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of PC-3 cells using CSB-PA623901LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE1C Polyclonal antibody
  • Uniprot No.：
    Q14123
  • 基因名：
  • 别名：
    5''-cyclic nucleotide phosphodiesterase 1C antibody; Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody; Calcium/calmodulin-dependent 3'' antibody; Cam PDE 1C antibody; Cam-PDE 1C antibody; hCam 3 antibody; hCam-3 antibody; HCAM3 antibody; HSPDE1C1A antibody; Human 3'5' cyclic nucleotide Phosphodiesterase antibody; PDE 1C antibody; Pde1c antibody; PDE1C_HUMAN antibody; Phosphodiesterase 1C antibody; Phosphodiesterase 1C calmodulin dependent antibody; Phosphodiesterase 1C calmodulin dependent 70kDa antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C protein (542-634AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDE1C Antibody (CSB-PA623901LA01HU)，的标记方式是Non-conjugated。对于PDE1C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA623901LB01HU PDE1C Antibody, HRP conjugated ELISA
    FITC CSB-PA623901LC01HU PDE1C Antibody, FITC conjugated
    Biotin CSB-PA623901LD01HU PDE1C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
  • 基因功能参考文献：
    1. PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro. PMID: 25620587
    2. PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1. PMID: 25608528
    3. PDE1C levels decreased in all conditions that inhibited proliferation PMID: 16455054
    4. PDE1C1 is expressed at high levels in human cardiac myocytes with an intracellular distribution distinct from that of PDE3A PMID: 17726023
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
  • 组织特异性：
    Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle. Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung. Also expressed at low levels in uterus and testis.
  • 数据库链接：

    HGNC: 8776

    OMIM: 602987

    KEGG: hsa:5137

    STRING: 9606.ENSP00000379496

    UniGene: Hs.143821