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PDCD2 Antibody

  • 货号：
    CSB-PA116985
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA116985(PDCD2 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA116985(PDCD2 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA116985(PDCD2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q16342
  • 基因名：
    PDCD2
  • 别名：
    MGC12347 antibody; OTTHUMP00000017702 antibody; PDCD 2 antibody; Pdcd2 antibody; PDCD2 protein antibody; PDCD2_HUMAN antibody; Programmed cell death 2 antibody; Programmed cell death protein 2 antibody; RP 8 antibody; RP8 antibody; Rp8 homolog antibody; Zinc finger MYND domain containing protein 7 antibody; Zinc finger MYND domain-containing protein 7 antibody; Zinc finger protein Rp 8 antibody; Zinc finger protein Rp-8 antibody; Zinc finger protein Rp8 antibody; ZMYND 7 antibody; ZMYND7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human PDCD2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
  • 基因功能参考文献：
    1. PDCD2 and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad signaling pathway. PMID: 26589942
    2. PDCD2 may play an important role in tumor suppression in osteosarcoma. These mechanisms might be related to immune response induced by CD4(+) and CD8(+) T cells. PMID: 26617804
    3. Low PDCD2 expression is associated with gastric cancer. PMID: 25111461
    4. Loss of PDCD2 expression could contribute to gastric cancer development and progression. PMID: 25334010
    5. Expression of human PDCD2 fully rescues the Drosophila Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. PMID: 24381196
    6. PDCD2 RNA expression in acute leukemia patients correlates with disease status and is a significant predictor of clinical relapse. PMID: 23760497
    7. PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development. PMID: 22922207
    8. Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase cascade. PMID: 20605493
    9. To study the role of PDCD2_C domain in apoptosis, the cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2. PMID: 16311922
    10. repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas PMID: 17468402

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 8762

    OMIM: 600866

    KEGG: hsa:5134

    STRING: 9606.ENSP00000439467

    UniGene: Hs.367900