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PCSK5 Antibody

  • 货号：
    CSB-PA017644LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of Hela cells using CSB-PA017644LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, Rat kidney tissue
      All lanes: PCSK5 antibody at 6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 207, 102 kDa
      Observed band size: 102 kDa
    • IHC image of CSB-PA017644LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PCSK5 Polyclonal antibody
  • Uniprot No.：
    Q92824
  • 基因名：
    PCSK5
  • 别名：
    FLJ11149 antibody; FLJ16215 antibody; hPC6 antibody; PC5 antibody; PC6 antibody; PC6A antibody; Pcsk5 antibody; PCSK5_HUMAN antibody; Prohormone convertase 5 antibody; Proprotein convertase 5 antibody; Proprotein convertase 6 antibody; Proprotein convertase PC5 antibody; Proprotein convertase subtilisin/kexin type 5 antibody; Protease PC6 antibody; SPC6 antibody; Subtilisin/kexin-like protease PC5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Proprotein convertase subtilisin/kexin type 5 protein (201-500AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PCSK5 Antibody (CSB-PA017644LA01HU)，的标记方式是Non-conjugated。对于PCSK5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017644LB01HU PCSK5 Antibody, HRP conjugated ELISA
    FITC CSB-PA017644LC01HU PCSK5 Antibody, FITC conjugated
    Biotin CSB-PA017644LD01HU PCSK5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
  • 基因功能参考文献：
    1. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
    2. Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene. PMID: 26055999
    3. full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation PMID: 26077903
    4. Proprotein convertase 5/6 cleaves PDGFA in the human endometrium in preparation for embryo implantation. PMID: 25429785
    5. PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 signaling pathway. PMID: 25350918
    6. study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas PMID: 22740495
    7. PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization. PMID: 21971156
    8. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. PMID: 21700711
    9. PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility PMID: 21273245
    10. PTPkappa was scissored by the processed form of proprotein convertase 5, and galectin-3 binding protein which is over-produced in colon cancer cells and tissues. PMID: 21094132
    11. The proteolytic activation and thus bioavailability of BMP2 is controlled by PC6. PMID: 20555025
    12. Variability at the PCSK5 locus influences high-density lipoprotein cholesterol levels. PMID: 20031622
    13. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
    14. PC5/6 plays a key role for decidualization in human endometrium. PMID: 15522936
    15. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation PMID: 15601911
    16. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only PMID: 17242158
    17. after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. PMID: 18039650
    18. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639

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  • 亚细胞定位：
    [Isoform PC6A]: Secreted.; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein.
  • 蛋白家族：
    Peptidase S8 family
  • 组织特异性：
    Expressed in T-lymphocytes.
  • 数据库链接：

    HGNC: 8747

    OMIM: 600488

    KEGG: hsa:5125

    STRING: 9606.ENSP00000446280

    UniGene: Hs.368542