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PCP4 Antibody

  • 货号：
    CSB-PA905587
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA905587(PCP4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P48539
  • 基因名：
    PCP4
  • 别名：
    Brain specific antigen PCP 4 antibody; Brain specific polypeptide PEP 19 antibody; Brain specific polypeptide PEP19 antibody; Brain-specific antigen PCP-4 antibody; Brain-specific polypeptide PEP-19 antibody; OTTHUMP00000109191 antibody; Pcp4 antibody; PCP4_HUMAN antibody; PEP19 antibody; Purkinje cell protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human PCP4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:5-1:20
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways.
  • 基因功能参考文献：
    1. PCP4 promoter was one of the most hypomethylated in aldosterone-producing adenoma and PCP4 transcription may be associated with demethylation as well as with CEBPA in APAs. PMID: 29294065
    2. PCP4/PEP19 has a role in promoting migration, invasion and adhesion in human breast cancer cells PMID: 27384474
    3. Data indicated that PCP4/PEP19 regulates apoptosis but exact mechanism is still unknown. PMID: 25153723
    4. PCP4 protein is highly expressed in the olfactory bulb and caudate putamen and PCP4 expressing cells in the brain are of neuronal origin. PMID: 24954028
    5. PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells. PMID: 24403568
    6. This study demonstrate that Pcp4 overexpression extended these effects later in development by modulating genes in line with the maturation of neurons in the cerebellum. PMID: 24291518
    7. The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release. PMID: 23204517
    8. Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation. PMID: 21491429
    9. The PCP4 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    10. PEP-19 has the potential to alter the Ca2+-binding dynamics of free CaM and CaM that is bound to other target proteins PMID: 14551202

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  • 蛋白家族：
    PCP4 family
  • 数据库链接：

    HGNC: 8742

    OMIM: 601629

    KEGG: hsa:5121

    STRING: 9606.ENSP00000329403

    UniGene: Hs.80296