PCM1 Antibody

1. In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly. PMID: 27146717
2. Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein) PMID: 28620049
3. a novel variant in the PCM1 3'UTR is significantly associated with ovarian cancer PMID: 24909162
4. no association between the PCM1 gene and schizophrenia in a Japanese population PMID: 24576429
5. Haematological neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 have features in common and we suggest that they should be recognized as a specific entity in the WHO classification PMID: 24913195
6. these data suggest a mechanism whereby the recruitment of Plk1 to pericentriolar matrix by PCM1 plays a pivotal role in the regulation of primary cilia disassembly before mitotic entry. PMID: 23345402
7. Chromosomal translocation [t(8;9)(p22;p24)]/PCM1-JAK2 fusion protein activates SOCS2 and SOCS3 via STAT5 in a cutaneous T-cell lymphoma cell line. PMID: 23372669
8. CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation. PMID: 23110211
9. PCM1 interacts with Hook2 in a complex that regulates a limiting step required for further initiation of ciliogenesis after centriole maturation. PMID: 21998199
10. NEK7 is essential for PCM accumulation in a cell cycle stage-specific manner. PMID: 22100915
11. WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1). PMID: 21985783
12. The data failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>0.28). PMID: 21481569
13. These data provide further evidence that PCM1-though certainly not a major risk factor in the Northern Swedish population-cannot be ruled out as a contributor to schizophrenia risk and/or protection. PMID: 20468070
14. DISC1 coding variants modulate centrosomal PCM1 localization, highlight a role for DISC1 in glial function and provide a possible cellular mechanism contributing to the association of these DISC1 variants with psychiatric phenotypes. PMID: 20360304
15. Hook3- and PCM1-mediated dynamic assembly of pericentriolar material is essential for interkinetic nuclear migration. PMID: 20152126
16. multiple processes involved in regulating the abundance of NIMA (never in mitosis gene a)-related kinase 2 kinase at the centrosome including microtubule binding, the centriolar satellite component PCM-1, and localized protein degradation PMID: 15659651
17. To study the rearrangement created by the t(8;9)(p22;p24)used dual-colour FISH on metaphases from patient cells using labelled-BAC clones centred on PCM1. PMID: 16034466
18. A genetic translocation in atypical chronic myeloid leukemia yields a new PCM1-JAK2 fusion gene. PMID: 16091753
19. The PCM1 gene is implicated in susceptibility to schizophrenia and is associated with orbitofrontal gray matter volumetric deficits. PMID: 16894060
20. cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression PMID: 18594780
21. PCM1 gene is implicated in schizophrenia. PMID: 18762586
22. CEP290 binds to PCM-1 and localizes to centriolar satellites in a PCM-1- and microtubule-dependent manner. PMID: 18772192
23. decreased colocalization of DISC1 and its binding partner PCM1 after Phe607 DISC1 transfection PMID: 19455170

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A chromosomal aberration involving PCM1 is found in papillary thyroid carcinomas (PTCs). Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1.

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruitment to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling.

PCM1 family

Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.

HGNC: 8727

OMIM: 600299

KEGG: hsa:5108

STRING: 9606.ENSP00000327077

UniGene: Hs.491148