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PCDH17 Antibody

  • 货号：
    CSB-PA017530LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of U251 cells with CSB-PA017530LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PCDH17 Polyclonal antibody
  • Uniprot No.：
    O14917
  • 基因名：
    PCDH17
  • 别名：
    Protocadherin-17 (Protocadherin-68), PCDH17, PCDH68 PCH68
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protocadherin-17 protein (18-243aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PCDH17 Antibody (CSB-PA017530LA01HU)，的标记方式是Non-conjugated。对于PCDH17 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017530LB01HU PCDH17 Antibody, HRP conjugated ELISA
    FITC CSB-PA017530LC01HU PCDH17 Antibody, FITC conjugated
    Biotin CSB-PA017530LD01HU PCDH17 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potential calcium-dependent cell-adhesion protein.
  • 基因功能参考文献：
    1. Methylation of PCDH17 could play an important role in development and progression of high-grade serous ovarian carcinoma (HGSOC)and has potential to become a target in the search for new clinical biomarkers PMID: 29991130
    2. PCDH17 methylation in serum is a potential prognostic biomarker for patients with renal cell carcinoma after surgery. PMID: 28688232
    3. PCDH17 functions as a tumor suppressor inhibiting Wnt/beta-catenin signaling and metastasis in breast cancer but is frequently methylated in primary tumors which could be a potential biomarker. PMID: 27351130
    4. Aberrant methylation of protocadherin 17 is associated with acute lymphoblastic leukemia. PMID: 27643535
    5. PCDH-17 inhibited metastasis via EGFR/MEK/ERK signaling pathway. PMID: 26386721
    6. DNA methylation in a combination of POU4F2/PCDH17 has yielded the highest sensitivity and specificity of 90.00% and 93.96% in all the 312 individuals, showing the capability of detecting bladder cancer effectively among pathologically varied sample groups. PMID: 26700620
    7. PCDH17 methylation in serum is a frequent event in early-stage prostate cancer, and it is an independent predictor of BCR after radical prostatectomy PMID: 26683656
    8. PCDH17 methylation occurred more frequently and was associated with malignant clinicopathological characteristics and poor prognosis in clear cell renal cell carcinoma patients PMID: 26404644
    9. PCDH17 promoter methylation is closely associated with bladder cancer malignancy and may be used as an independent predictor of clinical outcomes in patients with bladder cancer. PMID: 24567353
    10. PCDH17 promoter methylation was significantly associated with malignant behaviour and poor prognosis of bladder cancer PMID: 24366498
    11. This study demonistrated that critical role for PCDH17 in the synaptic development of specific corticobasal ganglia circuits and suggest the involvement of PCDH17 in such circuits in depressive behaviors. PMID: 23684785
    12. PCDH17 acts as a tumour suppressor, exerting its anti-proliferative activity through inducing apoptosis and autophagy, and is frequently silenced in gastric and colorectal cancers. PMID: 22926751
    13. Our study clearly demonstrates that PCDH17 is transcriptionally downregulated in gastric cancer due to aberrant promoter CpG island methylation PMID: 22207556
    14. statistical significant downregulation of PCDH17/PCH68 and PTPRD was observed PMID: 21213369
    15. results suggest that silencing of PCDH17 expression through hypermethylation of the promoter or other mechanisms leads to loss of its tumour-suppressive activity, which may be a factor in the carcinogenesis of a subgroup of ESCCs PMID: 20200074
    16. Azoospermic testis showed down-regulation of CDH18 and PCDH17. PMID: 20180417
    17. the apparent occurrence of an unusual TG 3' splice site in intron 2 is discussed PMID: 17672918

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 14267

    OMIM: 611760

    KEGG: hsa:27253

    UniGene: Hs.106511