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PAXBP1 Antibody

  • 货号：
    CSB-PA003778GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y5B6
  • 基因名：
    PAXBP1
  • 别名：
    BM 020 antibody; BM020 antibody; Chromosome 21 open reading frame 66 antibody; FSAP105 antibody; Functional spliceosome-associated protein 105 antibody; GC rich sequence DNA binding factor candidate antibody; GC-rich sequence DNA-binding factor 1 antibody; GCFC antibody; GCFC1 antibody; GCFC1_HUMAN antibody; PAX3 and PAX7 binding protein 1 antibody; PAXBP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human C21orf66
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20.
  • 基因功能参考文献：
    1. A homozygous potentially pathogenic variant in the PAXBP1 gene in a large family with global developmental delay and myopathic hypotonia has been reported. PMID: 28542722
    2. The GCFC1/C21orf66 distal promoter contains an inhibitory cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    GCF family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 13579

    OMIM: 617621

    KEGG: hsa:94104

    STRING: 9606.ENSP00000328992

    UniGene: Hs.644004