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PAX7 Antibody

  • 货号：
    CSB-PA891015
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA891015(PAX7 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P23759
  • 基因名：
    PAX7
  • 别名：
    FLJ37460 antibody; HUP1 antibody; OTTHUMP00000002534 antibody; Paired box 7 antibody; Paired box gene 7 antibody; Paired box homeotic gene 7 antibody; Paired box protein Pax-7 antibody; Paired domain gene 7 antibody; Paired domain gene HuP1 antibody; Pax7 antibody; PAX7 transcriptional factor antibody; PAX7/FKHR fusion gene, included antibody; PAX7_HUMAN antibody; PAX7B antibody; RGD1564360 antibody; RMS2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human PAX7
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

引用文献

产品评价

靶点详情

  • 功能：
    Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.
  • 基因功能参考文献：
    1. Data suggest that paired box gene 7 protein (PAX7) target gene repression is a hallmark of facioscapulohumeral muscular dystrophy (FSHD) that should be considered in the investigation of FSHD pathology and therapy. PMID: 29255294
    2. Transfection experiments showed that the PAX7 splice-site mutation putatively causes nonsense-mediated mRNA decay affecting onlyPAX7 isoform 3. PMID: 28779497
    3. The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain. PMID: 28935672
    4. EWSR1 fusion protein is required for PAX7 expression in Ewing sarcoma and identify a candidate EWSR1-FLI1-bound PAX7 enhancer that coincides with both a consensus GGAA repeat-containing binding site and a peak of regulatory H3K27 acetylation. PMID: 28643791
    5. miR-206 acts as a tumor suppressor in fusion-negative RMS at least partially through downregulation of PAX7. PMID: 27277678
    6. PAX7 expression is a useful marker of skeletal muscle differentiation in rhabdomyosarcoma, particularly of the embryonal subtype, with specificity for rhabdomyosarcoma and Ewing sarcoma. PMID: 27526298
    7. NTN1 rs9788972 is identified as a risk locus for nonsyndromic orofacial clefts susceptibility in a northern Chinese population; SNPs in PAX7 were not associated with any increased risk PMID: 28489749
    8. RAGE upregulates myogenin which upregulates MyoD and downregulates PAX7, with consequent inhibition of proliferation and stimulation of differentiation. PMID: 24554430
    9. Pax7 responds to NF-kappaB by impairing the regenerative capacity of myogenic cells in the muscle microenvironment to drive muscle wasting in cancer. PMID: 24084740
    10. High prevalence of 1p36 microdeletions in B-cell non-Hodgkin lymphomas is associated with PAX7 loss. PMID: 23205730
    11. Our study replicated previous GWAS findings for markers in VAX1 in the Asian population, and identified rare variants in PAX7 and VAX1 that may contribute to the etiology of CL(P) PMID: 23463464
    12. In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample. PMID: 23512105
    13. SUMOylation of Pax7 is essential for neural crest development in chick embryos and for the inhibitory roles of Pax7 in C2C12-muscle differentiation. PMID: 23247248
    14. PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation. PMID: 22374423
    15. Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury and disease. PMID: 21954137
    16. MyoD can play an active role in Alveolar rhabdomyosarcoma by augmenting Pax7-FKHR function. PMID: 21321994
    17. PAX7-FKHR gene fusion is prognostic indicator for alveolar rhabdomyosarcoma. PMID: 12039929
    18. expression of PAX7 is correlated with metastasis potential--REVIEW PMID: 12647804
    19. elevated PAX7 expression indicates myogenic satellite cell origin for embryonal rhabdomyosarcoma PMID: 12865925
    20. in the RD embryonal rhabdomyosarcoma cell line, expression of wild-type PAX7 is downregulated by PAX3-FKHR PMID: 15184910
    21. PAX 7-FKHR fusion transcripts were positive in 2/7 of alveolar rhabdomyosarcoma patients, and were negative in embryonal rhabdomyosarcoma and Control tumors. PMID: 17285543
    22. Results identified a differentiation-resistant skeletal muscle progenitor cell population that was Pax7+/desmin- and capable of self-renewal. PMID: 19097049
    23. TAT analysis of all trios revealed two SNPs in PAX7 showing significant excess maternal transmission Isolated cleft lip with or without cleft palate PMID: 19142206

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  • 相关疾病：
    Rhabdomyosarcoma 2 (RMS2)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 数据库链接：

    HGNC: 8621

    OMIM: 167410

    KEGG: hsa:5081

    STRING: 9606.ENSP00000364524

    UniGene: Hs.113253